781664-81-1

Basic information

• Product Name: (S)-Methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido
• Synonyms: (S)-Methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido;Trityl valsartan methyl ester;(S)-Methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanam;L-Valine,N-(1-oxopentyl)-N-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-, methyl ester;(S)-Methyl 3-methyl-2-(N-((2-(1-trityl-1H-tetrazol-5-yl)-[1,1-biphenyl]-4-yl)methyl)pentanamido)butanoate
• CAS NO: 781664-81-1
• Molecular Formula: C₄₄H₄₅N₅O₃
• Molecular Weight: 691.8598
• EINECS: 1312995-182-4
• Mol File: 781664-81-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-Methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido(781664-81-1)
• EPA Substance Registry System: (S)-Methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido(781664-81-1)

Safety Data

• Hazardous Substances Data: 781664-81-1(Hazardous Substances Data)

Usage

General Description

(S)-Methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido is a complex organic compound that contains a trityl-1H-tetrazol-5-yl group, a biphenyl group, and a pentanamido group. The compound also contains methyl and methyl-3 groups. It is a chiral molecule, as indicated by the (S)- prefix in its name. (S)-Methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido is likely to have a range of chemical properties and potential uses, but further analysis and testing would be needed to fully understand its characteristics and potential applications.

Upstream product

• 638-29-9 n-valeryl chloride 
• 1000986-63-9 N-[[2'-(1-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]valine methyl ester oxalate 
• 144873-97-2 2-(N-triphenylmethyl-tetrazol-5-yl)-phenylboronic acid 
• 894793-34-1 methyl N-[4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)phenyl-4-yl-methyl]-L-valinate 
• 143945-72-6 N-trityl-5-(2-bromophenyl)tetrazole 
• 883223-09-4 N-pentanoyl-N-[4-(4′,4′,5′,5′-tetramethyl-1′,3′,2′-dioxaborolan-2'-yl)benzyl]-L-valinemethyl ester 
• 154750-11-5 N-(triphenylmethyl)phenyltetrazole 

Downstream Products

• 137863-17-3 methyl N-((2’-(1H-tetrazol-5-yl)-[1,1’-biphenyl]-4-yl)methyl)-N-pentanoyl-L-valinate 
• 596-31-6 methoxytriphenylmethane 
• 137862-53-4 N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine 

Relevant articles and documents

A short and efficient synthesis of valsartan via a Negishi reaction

An efficient synthesis of the angiotensin-II inhibitor valsartan (Diovan) is presented. Directed ortho-metalation of 5-phenyl-1-trityl-1H- tetrazole (6) and its Negishi coupling with aryl bromide 5 are the key steps of the synthesis. This method overcomes

Process For the Preparation of Angiotensin II Antagonist

The present invention provides a method for the preparation of N-(1-oxopentyl)-N-[[2′-(1H-tetra-zol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine (Valsartan) which comprises; treating N-[[2′-(1-triphenylmethyl-tetra-zol-5-yl)biphenyl-4-yl]methyl]-L-valine me

PROCESS FOR PREPARING VALSARTAN

Provided is a process for preparing valsartan and precursors thereof.