782-78-5Relevant articles and documents
Synthesis, vibrational spectral and nonlinear optical studies of N-(4-hydroxy-phenyl)-2-hydroxybenzaldehyde-imine: A combined experimental and theoretical investigation
Wang, Yufeng,Yu, Zongxue,Sun, Yuxi,Wang, Yishi,Lu, Lude
, p. 1475 - 1482 (2011)
The study of imine-bridged organics has been the one hot spot of photo-responsive material sciences in recent years. Herein we make a study of the synthesis, characteristics and potential application of N-(4-hydroxy-phenyl) -2-hydroxy-benzaldehyde-imine (
The benzoxazine compounds, its manufacturing method and a benzoxazine resin
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Paragraph 0054-0056, (2021/06/03)
The present invention provides a novel benzoxazine compound represented by formula (1), from which a highly heat-resistant cured product can be obtained. The present invention also provides a method for producing a benzoxazine compound, the method includi
Synthesis and molecular docking studies of imines as α-glucosidase and α-amylase inhibitors
Aispuro-Pérez, Analy,Bastidas, Pedro,Calderón-Zamora, Loranda,García-Páez, Fernando,López-ávalos, Juan,Monta?o, Sarita,Montes-Avila, Julio,Ochoa-Terán, Adrián,Osuna-Martínez, Ulises,Picos-Corrales, Lorenzo A.,Sarmiento-Sánchez, Juan I.
, (2019/12/25)
Imine functionality is found in many compounds with important biological activity. Thus, the development of novel synthetic approaches for imines is important. In this work, it is propose an easy, eco-friendly and straightforward synthesis pathway of aryl imines under microwave irradiation catalyzed by Alumina-sulfuric acid. In addition, the in vitro enzymatic inhibition, antioxidant activity and molecular docking studies were performed. The aryl imines were isolated with yields in the range of 37–94%. All aryl imines synthesized were evaluated for in vitro inhibitory potential against α-glucosidase and α-amylase enzymes and the results exhibited that the most of the compounds displayed inhibitory activity against both enzymes. The (E)-1-(4-nitrophenyl)-N-(pyridin-2-yl)methanimine (3d) was 1.15-fold more active than acarbose against α-amylase whilst the (E)-1-phenyl-N-(pyridin-2-yl)methanimine (3c) displayed similar activity that acarbose against α-glucosidase. The molecular docking studies in α-glucosidase and α-amylase reveal that aryl imines mainly establish an H-bond with the R2-subtituent and hydrophobic interactions with the R1-subtituent. The docking analysis reveals these synthetic aryl imines 3d-i interact in same active site than acarbose drug in both enzymes.