78266-75-8Relevant articles and documents
Sequential α-ketoacid-hydroxylamine (KAHA) ligations: Synthesis of C-terminal variants of the modifier protein UFM1
Ogunkoya, Ayodele O.,Pattabiraman, Vijaya R.,Bode, Jeffrey W.
, p. 9693 - 9697,5 (2012/12/11)
3 for 3: Sequential α-ketoacid-hydroxylamine (KAHA) ligations with 5-oxaproline allow access to the modifier protein UFM1 (Ubiquitin-fold modifier 1) with a C-terminal amide, carboxylic acid, or a masked thioester. Fmoc protection of an N-terminal 5-oxaproline permits the assembly of proteins of >80 residues in good yield by a two-pot process from three readily prepared medium-sized protein segments. Copyright