78383-17-2

Basic information

• Product Name: 4-phenyl-2,3-dihydro-1H-inden-1-one
• Synonyms: 4-Phenylindan-1-One
• CAS NO: 78383-17-2
• Molecular Formula: C₁₅H₁₂O
• Molecular Weight: 208.2552
• Mol File: 78383-17-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 390.6°C at 760 mmHg
• Flash Point: 173.8°C
• Density: 1.155g/cm³
• Vapor Pressure: 2.62E-06mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 4-phenyl-2,3-dihydro-1H-inden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenyl-2,3-dihydro-1H-inden-1-one(78383-17-2)
• EPA Substance Registry System: 4-phenyl-2,3-dihydro-1H-inden-1-one(78383-17-2)

Safety Data

• Hazardous Substances Data: 78383-17-2(Hazardous Substances Data)

Usage

General Description

4-phenyl-2,3-dihydro-1H-inden-1-one, also known as dihydrobenzofuran-3(2H)-one, is a chemical compound with the molecular formula C15H12O. It is a white to off-white crystalline powder that is commonly used in the synthesis of pharmaceutical compounds and as a building block in organic chemistry. 4-phenyl-2,3-dihydro-1H-inden-1-one has a variety of applications in the fields of medicine, agriculture, and material science, and it is known to exhibit antimicrobial and antioxidant properties. Additionally, 4-phenyl-2,3-dihydro-1H-inden-1-one has been identified as a potential candidate for the development of new drugs and biologically active molecules due to its unique structure and reactivity.

Upstream product

• 19853-17-9 3-(biphenyl-2-yl)propanoic acid 
• 75-15-0 carbon disulfide 
• 7719-09-7 thionyl chloride 
• 335159-82-5 3-(m-bromophenyl)propionyl chloride 
• 42287-90-1 3-(3-bromophenyl)propanoic acid 
• 15115-60-3 4-bromo-2,3-dihydroinden-1-one 
• 98-80-6 phenylboronic acid 

Downstream Products

• 954-06-3 biphenyl-2,3-dicarboxylic acid anhydride 
• 111538-45-5 2-bromo-5-fluoro-1-indanone 
• 78383-18-3 4-phenyl-2,3-dihydro-1H-inden-1-ol 
• 1354727-90-4 C₂₂H₁₈O₂ 
• 1354727-99-3 C₂₂H₁₈O₂ 
• 1354728-07-6 C₂₂H₁₆O 
• 1354727-79-9 C₂₂H₁₈ 
• 78383-19-4 7-phenylindene 

Relevant articles and documents

Enantioselective Synthesis of Chiral Indane Derivatives by Rhodium-Catalyzed Addition of Arylboron Reagents to Substituted Indenes

Rhodium-catalyzed asymmetric addition of arylboron reagents to indene derivatives proceeded to give 2-arylindanes in good yields with high enantioselectivity. Deuterium-labeling experiments indicated that the present reaction involved a 1,4-Rh shift from an initially formed benzylrhodium to an arylrhodium intermediate before protonation leading to the corresponding addition product. The asymmetric addition was also successful for acenaphthylene, which has a similar skeleton to indene, where it was found that the benzylrhodium intermediate underwent direct protonation without the 1,4-Rh shift.

IMMUNOMODULATOR COMPOUNDS

Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

THERAPEUTIC AGENTS

The invention provides well-defined compounds that are either EP2 agonists, EP4 agonists, or mixed EP2/EP4 agonist. The compounds are useful for treating a variety of pathological conditions associated with acti