784144-71-4Relevant articles and documents
Phosphine-Catalyzed [3 + 2] Annulation of Morita-Baylis-Hillman Carbonates with Isoxazole-Based Alkenes
Liao, Jianning,Dong, Jipan,Xu, Jiaqing,Wang, Wei,Wu, Yongjun,Hou, Yuxia,Guo, Hongchao
supporting information, p. 2090 - 2099 (2021/02/05)
A phosphine-catalyzed [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford various multifunctional isoxazoles in moderate to good yields with moderate to excellent diastereoselectivities. With a spirocyclic chiral phosphine as the catalyst, up to 89% ee was obtained.
Factors influencing the cytotoxicity of α-methylene-γ-hydroxy esters against pancreatic cancer
Ramachandran, P. Veeraraghavan,Helppi, Matthew A.,Lehmkuhler, Arlie L.,Marchi, Jennifer M.,Schmidt, C. Max,Yip-Schneider, Michele T.
supporting information, p. 4270 - 4273 (2015/11/03)
A systematic study to identify the factors influencing the cytotoxicity of α-methylene-γ-hydroxy esters against three pancreatic cancer cell lines (Panc-1, MIA-PaCa-2, and BxPC-3) has established that, in addition to Michael acceptor abilities, the possibility to lactonize to α-methylene-γ-butyrolactones is as important. The substitution pattern and the number of carbons between the hydroxy and ester moieties also influence the bio-activity.
Syntheses of β- And γ-fluorophenyl cis- and trans-α-methylene-γ-butyrolactones
Ramachandran, P. Veeraraghavan,Nair, Hari Narayanan G.,Gagare, Pravin
supporting information, p. 5722 - 5726 (2015/02/05)
Preparation of a series of cis-γ-fluorophenyl-β-phenyl-α-methylene-γ-butyrolactones is reported via 'allylboration' of fluorobenzaldehydes with (E)-methyl 3-phenyl-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)acrylate. The corresponding trans-γ-
