78441-23-3

Basic information

• Product Name: 3,4-DiMethoxy-1,2,5-thiadiazole 1-oxide
• Synonyms: 3,4-DiMethoxy-1,2,5-thiadiazole 1-oxide;3,4-dimethoxy-2,5-dihydro-1,2,5-thiadiazole 1-oxide;3,4-DIMETHOXY-1,2,5-THIADIAZOLE 1-OXIDE(WXG02349)
• CAS NO: 78441-23-3
• Molecular Formula: C₄H₆N₂O₃S
• Molecular Weight: 162.16704
• Mol File: 78441-23-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 135-137 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 232.1±23.0 °C(Predicted)
• Appearance: /
• Density: 1.65±0.1 g/cm3(Predicted)
• PKA: -2.34±0.20(Predicted)
• CAS DataBase Reference: 3,4-DiMethoxy-1,2,5-thiadiazole 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DiMethoxy-1,2,5-thiadiazole 1-oxide(78441-23-3)
• EPA Substance Registry System: 3,4-DiMethoxy-1,2,5-thiadiazole 1-oxide(78441-23-3)

Safety Data

• Hazardous Substances Data: 78441-23-3(Hazardous Substances Data)

Upstream product

• 13534-15-1 diethyl oximidate 
• 55904-37-5 3,4-dimethoxy-1,2,5-thiadiazole 
• 30986-09-5 oxaldiimidic acid dimethyl ester 
• 67-56-1 methanol 
• 79844-64-7 3,4-Diethyloxy-1-oxo-1,2,5-thiadiazole 

Downstream Products

• 105918-10-3 3-[3-[N-(4-fluorobenzyl)-N-pyrid-2-ylamino]propylamino]-4-pyrimidin-4-ylmethylamino-1,2,5-thiadiazole-1-oxide 
• 93364-63-7 3-[3-[N-(4-fluorobenzyl)-N-(2-pyridyl)amino]propylamino]-4-methylamino-1,2,5-thiadiazole-1-oxide 
• 93364-62-6 3-[3-[N-(4-fluorobenzyl)-N-(2-pyridyl)amino]propylamino]-4-amino-1,2,5-thiadiazole-1-oxide 
• 93364-56-8 3-[4-(N-benzyl-N-(2-pyridyl)amino)butylamino)-4-amino-1,2,5-thiadiazole-1-oxide 
• 93364-39-7 3-[3-(N-benzyl-N-(2-pyridyl)amino)propylamino]-4-methylamino-1,2,5-thiadiazole-1-oxide 
• 93364-55-7 3-[3-(N-benzyl-N-(2-pyridyl)amino)propylamino]-4-amino-1,2,5-thiadiazole-1-oxide 
• 93364-67-1 3-[3-(N-benzyl-N-(2-pyridyl)amino)propylamino]-4-[3-pyridylmethyl]amino-1,2,5-thiadiazole-1-oxide 
• 93364-66-0 3-[3-(N-benzyl-N-(2-pyridyl)amino)propylamino]-4-[2-pyridylmethyl]amino-1,2,5-thiadiazole-1-oxide 
• 93364-73-9 3-[3-(N-(4-fluorobenzyl)-N-(2-pyridyl)amino)propylamino]-4-[4-pyridylmethyl]amino-1,2,5-thiadiazole-1-oxide 
• 93364-68-2 3-[3-(N-benzyl-N-(2-pyridyl)amino)propylamino]-4-[4-pyridylmethyl]amino-1,2,5-thiadiazole-1-oxide 
• 78441-87-9 3-amino-4-{2-[(3-{dimethylaminomethyl}phenyl)methylthio]ethylamino}-1,2,5-thiadiazole 1-oxide 
• 78441-84-6 NCI365351 
• 78442-39-4 3-Amino-4-[3-(3-piperidinomethylphenoxy)propylamino]-1,2,5-thiadiazole 1-oxide 
• 106940-02-7 4-(p-fluorobenzylamino)-3-[3-(5-bromo-3-methylpyrid-2-ylamino)propylamino]-1,2,5-thiadiazole-1-oxide 

Relevant articles and documents

SPECIFIC ANTAGONIST FOR BOTH E- AND P-SELECTINS

Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise a particular glycomimetic linked to a particular BASA (Benzyl Amino Sulfonic Acid).

HETEROCYCLIC COMPOUNDS

Compounds of Formula I are described STR1 in which X and Y are independently--NH--,--O--or--S--; Z may be a pyrimidine, triazine, triazole, thiazole, thiadiazole ring. The methods of preparation are described. The compounds are useful as antipeptic ulcer agents.

1,2,5-THIADIAZOLE-1-OXIDES. I. SYNTHESIS AND REACTIONS OF ALKOXY AND ALKYLTHIO ANALOGS

Diethoxy and dithiomethyl 1,2,5-thiadiazole oxides were synthesized from the corresponding oxalimidates with thionyl chlorides.The alkoxy and alkylthio groups were readily replaced by amines, carbon nucleophiles and hydroxide.The resulting hydroxy compounds were alkylated and acylated on the ring nitrogen.The N-alkyl product could be also obtained by thermal O to N rearrangement of the alkoxy derivatives.