78441-83-5

Basic information

• Product Name: N-{2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}-1,2,5-thiadiazole-3,4-diamine 1,1-dioxide
• Synonyms: 1,2,5-thiadiazole-3,4-diamine, N~3~-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-, 1,1-dioxide
• CAS NO: 78441-83-5
• Molecular Formula: C₁₂H₁₉N₅O₃S₂
• Molecular Weight: 345.441
• Mol File: 78441-83-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 490.3°C at 760 mmHg
• Flash Point: 250.3°C
• Density: 1.5g/cm³
• Vapor Pressure: 9.25E-10mmHg at 25°C
• Refractive Index: 1.674
• CAS DataBase Reference: N-{2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}-1,2,5-thiadiazole-3,4-diamine 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}-1,2,5-thiadiazole-3,4-diamine 1,1-dioxide(78441-83-5)
• EPA Substance Registry System: N-{2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}-1,2,5-thiadiazole-3,4-diamine 1,1-dioxide(78441-83-5)

Safety Data

• Hazardous Substances Data: 78441-83-5(Hazardous Substances Data)

Upstream product

• 66356-53-4 5-{[(2-aminoethyl)thio]methyl}-N,N-dimethyl-2-furfurylamine 
• 55904-83-1 3,4-dimethoxy-1,2,5-thiadiazole-1,1-dioxide 
• 81074-85-3 4-Ethoxy-1,1-dioxo-1H-1λ⁶-[1,2,5]thiadiazol-3-ylamine 

Relevant articles and documents

HISTAMINE H2-ANTAGONISTS

Histamine H 2-antagonists of the formula STR1 wherein p is 1 or 2; R 1 is hydroxy, amino, substituted amino or a 5-to 9-membered fully saturated nitrogen-containing heterocyclic ring attached via its nitrogen atom; m is an integer of from 0 to 2, n is an integer of from 2 to 4; Z is sulfur, oxygen or methylene; and A is an optionally substituted phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl ring; and nontoxic pharmaceutically acceptable salts, hydrates, solvates or N-oxides thereof are novel anti-ulcer agents. Intermediates and processes for their preparation are disclosed.

CHEMICAL COMPOUNDS

Histamine H 2-antagonists of the formula STR1 wherein p is 1 or 2; R 1 is hydroxy, amino, substituted amino or a 5-to 9-membered fully saturated nitrogen-containing heterocyclic ring attached via its nitrogen atom; m is an integer of from 0 to 2; n is an integer of from 2 to 4; Z is sulfur, oxygen or methylene; and A is an optionally substituted phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl ring; and nontoxic pharmaceutically acceptable salts, hydrates, solvates or N-oxides thereof are novel anti-ulcer agents. Intermediates and processes for their preparation are disclosed.

Inhibitors of Gastric Acid Secretion: 3,4-Diamino-1,2,5-thiadiazole 1-Oxides and 1,1-Dioxides as Urea Equivalents in a Series of Histamine H2-Receptor Antagonists

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