78451-00-0

Basic information

• Product Name: 2-Chloro-5-<(benzyloxy)methyl>-4-(trifluoromethyl)thiazole
• Synonyms: 2-Chloro-5-<(benzyloxy)methyl>-4-(trifluoromethyl)thiazole
• CAS NO: 78451-00-0
• Molecular Weight: 307.724
• Mol File: 78451-00-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Chloro-5-<(benzyloxy)methyl>-4-(trifluoromethyl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-<(benzyloxy)methyl>-4-(trifluoromethyl)thiazole(78451-00-0)
• EPA Substance Registry System: 2-Chloro-5-<(benzyloxy)methyl>-4-(trifluoromethyl)thiazole(78451-00-0)

Safety Data

• Hazardous Substances Data: 78451-00-0(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 78450-97-2 2-Chloro-4-(trifluoromethyl)-5-thiazolemethanol 
• 72850-53-4 ethyl 2,3-dihydro-2-oxo-4-trifluoromethyl-5-thiazole-carboxylate 
• 72850-52-3 ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate 

Relevant articles and documents

Syntheses and Reactions of 2-Halo-5-thiazolecarboxylates

A variety of 2-halo-5-thiazolecarboxylates was prepared from substituted-3-aminoacrylates and 3-ketoesters.Selective reduction of 2-chloro-5-thiazolecarboxylates 4a, 4i and 4j with sodium borohydride in ethanol provided the corresponding 2-halo-5-thiazolemethanols 27 - 29.Nucleophilic displacement on methyl methanesulfonate (32c) occured selectivity at the 5-substituent to provide 2-chloro-4-(trifluoromethyl)-5-(heteroatom-substituted methyl)thiazoles 32d-f.

2-Chloro-4,5-disubstituted-thiazoles useful as herbicidal safeners

2-chloro-4,5-disubstituted-thiazoles have been found to be effective in reducing herbicidal injury to sorghum plants due to the application thereto of acetanilide and thiocarbamate herbicides.