78463-34-0

Basic information

• Product Name: 4,6-dibromo-5-pentylbenzene-1,3-diol
• Synonyms: 4,6-dibromo-5-pentylbenzene-1,3-diol
• CAS NO: 78463-34-0
• Molecular Weight: 338.039
• Mol File: 78463-34-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4,6-dibromo-5-pentylbenzene-1,3-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dibromo-5-pentylbenzene-1,3-diol(78463-34-0)
• EPA Substance Registry System: 4,6-dibromo-5-pentylbenzene-1,3-diol(78463-34-0)

Safety Data

• Hazardous Substances Data: 78463-34-0(Hazardous Substances Data)

Upstream product

• 58016-28-7 methyl 2,6-dihydroxy-6-pentylbenzoate 
• 38228-29-4 1,3-dimethoxy-5-(pent-1-en-1-yl)benzene 
• 112639-04-0 2,4-dibromo-1,5-dimethoxy-3-pentylbenzene 
• 22976-40-5 1,3-dimethoxy-5-pentylbenzene 
• 500-66-3 Olivetol 
• 58016-30-1 5-n-amyl-2-bromocyclohex-2-ene-3-ol-1-one 

Downstream Products

• 13956-29-1 CBD 
• 74219-29-7 (1'S,2'S)-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-2,6-diol 

Relevant articles and documents

Design of Negative and Positive Allosteric Modulators of the Cannabinoid CB2Receptor Derived from the Natural Product Cannabidiol

Cannabidiol (CBD), the second most abundant of the active compounds found in the Cannabis sativa plant, is of increasing interest because it is approved for human use and is neither euphorizing nor addictive. Here, we design and synthesize novel compounds taking into account that CBD is both a partial agonist, when it binds to the orthosteric site, and a negative allosteric modulator, when it binds to the allosteric site of the cannabinoid CB2 receptor. Molecular dynamic simulations and site-directed mutagenesis studies have identified the allosteric site near the receptor entrance. This knowledge has permitted to perform structure-guided design of negative and positive allosteric modulators of the CB2 receptor with potential therapeutic utility.

PROCESSES FOR THE PREPARATION OF HALOGENATED DIHYDROXYBENZENE COMPOUNDS

The present disclosure relates to the preparation of halogenated dihydroxybenzene compounds with high yield, selectivity and purity. The compounds are useful, among other things, in the synthesis of cannabinoids and cannabinoid-type compounds.

Course of Aromatisation of 5-Alkyl/aryl-2-bromocyclohex-2-en-3-ol-1-ones to Corresponding 5-Alkyl/arylresorcinols

5-Alkyl/aryl-2-bromocyclohex-2-en-3-ol-1-ones on heating undergo aromatisation through dehydrobromination to the corresponding 5-substituted resorcinols.During the course of aromatisation of 2-bromo-5-methylcyclohex-2-en-3-ol-1-one (I) and 5-n-amyl-2-bromocyclohex-2-en-3-ol-1-one (II) a few intermediates have been isolated and characterised as IV, V, VI, VIII and IX.Similar studies on 2-bromo-5-phenylcyclohex-2-en-3-ol-1-one yields two structurally different products, one with no bromine (XI) and the other with bromine in position-2 (XII), besides 5-phenylresorcinol (XIII).