78541-97-6 Usage
Description
Piquindone is an atypical antipsychotic drug that acts as a selective D2 receptor antagonist. It is a promising pharmaceutical candidate for the treatment of various psychiatric disorders, including schizophrenia and Tourette's syndrome.
Uses
Used in Antipsychotic Applications:
Piquindone is used as an antipsychotic agent for the treatment of schizophrenia. It modulates the dopaminergic system by selectively blocking the D2 receptors, leading to a reduction in positive and negative symptoms associated with the disorder.
Used in Tourette's Syndrome Treatment:
Piquindone is used as a therapeutic agent for the treatment of Tourette's syndrome. Numerous clinical studies have demonstrated its effectiveness in managing the motor and vocal tics associated with the condition, improving the quality of life for affected individuals.
Check Digit Verification of cas no
The CAS Registry Mumber 78541-97-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,5,4 and 1 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 78541-97:
(7*7)+(6*8)+(5*5)+(4*4)+(3*1)+(2*9)+(1*7)=166
166 % 10 = 6
So 78541-97-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H22N2O/c1-4-11-9(2)16-13-7-10-5-6-17(3)8-12(10)15(18)14(11)13/h10,12,16H,4-8H2,1-3H3/t10-,12+/m0/s1
78541-97-6Relevant articles and documents
Syntheses of an Antipsychotic Pyrroloisoquinoline from Areca Alkaloids
Coffen, David L.,Hengartner, Urs,Katonak, David A.,Mulligan, Mary E.,Burdick, David C.,et al.
, p. 5109 - 5113 (2007/10/02)
2,6-Dimethyl-3-ethyl-4,4a,5,6,7,8,8a,9-octahydro-4a,8a-trans-1H-pyrroloisoquinolin-4-one, a conformationally defined antipsychotic agent of current clinical interest, can be synthesized in a two-step, single-pot process from arecoline, a commercially available member of the areca alkaloid group.The yield is diminished by the competing, base-induced rearrangement of arecoline to 1,3-dimethyl-2-pyridone.This problem can be circumvented by using arecolone as the starting material.A convenient synthesis of arecolone from 3-acetylpyridine is described.A modifiedform of the Neber rearrangement was used to prepare 2-amino-3-pentanone hydrochloride for use in the Knorr pyrrole synthesis step of the process.Two isomeric pyrroloisoquinolines produced as minor byproducts were isolated and characterized as the cis- and trans- isomers.Characterization of the latter included an X-ray crystal structure determination.
