78553-60-3

Basic information

• Product Name: T-BUTYL (2S)-2-[(BENZYLOXYCARBONYLAMINO)]-4-OXO-BUTYRATE
• Synonyms: T-BUTYL (2S)-2-[(BENZYLOXYCARBONYLAMINO)]-4-OXO-BUTYRATE;(2S)-4-Oxo-2-[[(phenylMethoxy)carbonyl]aMino]butanoic Acid 1,1-DiMethylethyl Ester
• CAS NO: 78553-60-3
• Molecular Formula: C₁₆H₂₁NO₅
• Molecular Weight: 307.34164
• Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Chiral Reagents
• Mol File: 78553-60-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 460.421°C at 760 mmHg
• Flash Point: 232.255°C
• Appearance: /
• Density: 1.148g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.51
• Solubility: Chloroform, Dichloromethane
• CAS DataBase Reference: T-BUTYL (2S)-2-[(BENZYLOXYCARBONYLAMINO)]-4-OXO-BUTYRATE(CAS DataBase Reference)
• NIST Chemistry Reference: T-BUTYL (2S)-2-[(BENZYLOXYCARBONYLAMINO)]-4-OXO-BUTYRATE(78553-60-3)
• EPA Substance Registry System: T-BUTYL (2S)-2-[(BENZYLOXYCARBONYLAMINO)]-4-OXO-BUTYRATE(78553-60-3)

Safety Data

• Hazardous Substances Data: 78553-60-3(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

InChI:InChI=1/C16H21NO5/c1-16(2,3)22-14(19)13(9-10-18)17-15(20)21-11-12-7-5-4-6-8-12/h4-8,10,13H,9,11H2,1-3H3,(H,17,20)/t13-/m0/s1

Upstream product

• 3160-47-2 N-(benzyloxycarbonyl)-L-aspartic acid 4-methyl ester 
• 4125-93-3 (S)-3-amino-4-(tert-butoxy)-4-oxobutanoic acid 
• 60079-12-1 β-Methyl α-tert-butyl (2S)-N-(benzyloxycarbonyl)aspartate 
• 78553-49-8 tert-butyl (S)-2-(benzyloxycarbonylamino)pent-4-enoate 
• 501-53-1 benzyl chloroformate 
• 78553-51-2 (S)-2-(benzyloxycarbonylamino)pent-4-enoic acid 
• 47307-26-6 (S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester 
• 78553-54-5 (S)-2-Benzyloxycarbonylamino-4,5-dihydroxy-pentanoic acid tert-butyl ester 
• 78266-81-6 tert-butyl N-[(benzyloxy)carbonyl]-L-homoserinate 

Downstream Products

• 147471-02-1 (2S)-^tbutyl N-(benzyloxycarbonyl)-2-amino-4-oxo pentanoate 
• 120286-24-0 (S)-2-(Benzyloxycarbonylamino)-4-dimethoxyphosphorylbutanoate 
• 120286-25-1 (2S)-2-{[(benzyloxy)carbonyl]amino}-4-(diethoxyphosphoryl)butanoic acid 
• 120286-22-8 tert-Butyl (S)-2-(benzyloxycarbonylamino)-4-dimethoxyphosphorylbutanoate 
• 120286-15-9 tert-Butyl (2S)-2-(benzyloxycarbonylamino)-4-dimethoxyphosphoryl-4-hydroxybutanoate 
• 120286-23-9 (S)-2-Benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-butyric acid tert-butyl ester 
• 120286-17-1 (S)-2-Benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-4-hydroxy-butyric acid tert-butyl ester 
• 120286-18-2 tert-Butyl (2S)-2-(benzyloxycarbonylamino)-4-dimethoxyphosphoryl-4-(imidazolylthiocarbonyloxy)butanoate 
• 120286-20-6 (S)-2-Benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-4-(imidazole-1-carbothioyloxy)-butyric acid tert-butyl ester 
• 901776-52-1 (S)-tert-butyl 4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)-2-(((benzyloxy)carbonyl)amino)butanoate 
• 1227195-11-0 (S)-tert-butyl 4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)-2-((tert-butoxycarbonyl)amino)butanoate 
• 153886-46-5 1,1-dimethylethyl (S,E)-2-[[(phenylmethoxy)carbonyl]amino]-5-[1-(triphenylmethyl)-1H-imidazol-4-yl]pent-4-enoate 
• 74235-24-8 2'-deoxymugineic acid 

Relevant articles and documents

NOVEL HISTONE METHYLTRANSFERASE INHIBITORS

The present invention relates to novel compounds of formula (I) as defined herein. The compounds are inhibitors of histone methyltransferases of the seven-beta-strand family, in particular of KMT9.

Development of rationally designed DNA N6 adenine methyltransferase inhibitors

A series of bisubstrate inhibitors for DNA N6 adenine methyltransferase (Dam) have been synthesized by linking an amine analogue of S-adenosylmethionine to an aryl moiety designed to probe the binding pocket of the DNA adenine base. An initial structure-activity relationship study has identified substituents that increase inhibitor potency to the ～10 μM range and improve selectivity against the human cytosine methyltransferase Dnmt1.

Synthesis of Optically Active 2-(tert-Butyloxycarbonylamino)-4-dialkoxyphosphorylbutanoate Protected Isosteres of O-Phosphonoserine for Peptide Synthesis

The preparation of (S)-2-(tert-butoxycarbonylamino)-4-dialkoxyphosphorylbutanoate from (S)-aspartic acid is described.