78594-13-5

Basic information

• Product Name: 1-(2,4-dimethylphenyl)-2-phenylacetylene
• Synonyms: 1-(2,4-dimethylphenyl)-2-phenylacetylene
• CAS NO: 78594-13-5
• Molecular Weight: 206.287
• Mol File: 78594-13-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1-(2,4-dimethylphenyl)-2-phenylacetylene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-dimethylphenyl)-2-phenylacetylene(78594-13-5)
• EPA Substance Registry System: 1-(2,4-dimethylphenyl)-2-phenylacetylene(78594-13-5)

Safety Data

• Hazardous Substances Data: 78594-13-5(Hazardous Substances Data)

Upstream product

• 1226156-14-4 3-(2,4-dimethylphenyl)propiolic acid 
• 80-17-1 benzenesufonyl hydrazide 
• 637-44-5 phenylpropyolic acid 
• 71-43-2 benzene 
• 108-38-3 m-xylene 
• 583-70-0 1-bromo-2,4-dimethylbenzene 
• 536-74-3 phenylacetylene 
• 4214-28-2 1-iodo-2,4-dimethylbenzene 
• 104213-87-8 2,4-dimethylphenyl phenylpropynoate 
• 78594-07-7 2-(2,4-Dimethyl-phenyl)-3-phenyl-cycloprop-2-enone 

Relevant articles and documents

Palladium-Catalyzed Decarboxylative Coupling Reactions of Propiolic Acid Derivatives and Arylsulfonyl Hydrazide

Arylsulfonyl hydrazides were employed as coupling partners for the decarboxylative coupling reaction of propiolic acid derivatives. When the reaction was conducted using Pd(TFA) 2 (1.0 mol%), dppp (1.0 mol%), and Cu(OAc) 2 (2.4 equiv

Copper-free Sonogashira cross-coupling reactions catalyzed by an efficient dimeric C,N-palladacycle in DMF/H2O

Very small concentrations of a dimeric C,N-palladacycle were used as an efficient homogeneous catalyst for Sonogashira cross-coupling reactions between various aryl halides and phenylacetylene. The catalytic reactions were performed without the need for copper in DMF/H2O. This catalytic system shows excellent yields for aryl iodides and bromides and even in the case of aryl chlorides.

Highly efficient Pd/tetraphosphine catalytic system for copper-free sonogashira reactions of aryl bromides with terminal alkynes

In this study, an easily synthesized polydentate ligand N,N,N',N'-tetra(diphenylphosphinomethyl)-1,2-ethylenediamine (1) in combination with [Pd(C3H5)Cl]2 was found to be an active catalyst in copper-free Sonogashira reactions. Most substrates, including steric hindered phenyl bromides and heteroaryl bromides, could couple efficiently with terminal alkynes in the presence of low catalyst loading (0.1 mol%) and this catalytic system showed excellent functional group tolerance. The influence of water in this system was also preliminarily investigated via 31P NMR in situ; that is, appropriate water favors the reaction while excess hindered this reaction.