78636-53-0 Usage
Description
2'-fluoro-5-methylarabino-furanosylcytosine, also known as FMAU, is a synthetic nucleoside analog that has demonstrated potential as an antiviral and antitumor drug. It is a fluorinated derivative of cytosine, a natural component of DNA and RNA, and the addition of a fluoro and methyl group to the sugar moiety of the cytosine molecule enhances its stability and inhibitory properties.
Uses
Used in Antiviral Applications:
2'-fluoro-5-methylarabino-furanosylcytosine is used as an antiviral agent for inhibiting the replication of certain viruses, such as herpes simplex virus and hepatitis B virus. Its enhanced stability and inhibitory properties make it a promising candidate for further drug development in this area.
Used in Antitumor Applications:
In the field of oncology, 2'-fluoro-5-methylarabino-furanosylcytosine is used as a potential cancer treatment, particularly for liver cancer. Its ability to inhibit tumor growth and progression, along with its potential for less toxicity and better selectivity compared to other nucleoside analogs, positions FMAU as a promising agent for cancer therapy.
Used in Pharmaceutical Development:
2'-fluoro-5-methylarabino-furanosylcytosine is utilized as a candidate for drug development due to its potential applications in both antiviral and antitumor therapies. Its unique properties and the ongoing research into its mechanisms of action and efficacy contribute to its value in the pharmaceutical industry for creating new treatment options.
Check Digit Verification of cas no
The CAS Registry Mumber 78636-53-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,6,3 and 6 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 78636-53:
(7*7)+(6*8)+(5*6)+(4*3)+(3*6)+(2*5)+(1*3)=170
170 % 10 = 0
So 78636-53-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H14FN3O4/c1-4-2-14(10(17)13-8(4)12)9-6(11)7(16)5(3-15)18-9/h2,5-7,9,15-16H,3H2,1H3,(H2,12,13,17)/t5-,6+,7-,9+/m1/s1
78636-53-0Relevant articles and documents
Probing Synergistic Effects of DNA Methylation and 2′-β-Fluorination on i-Motif Stability
Abou Assi, Hala,Lin, Yu Chen,Serrano, Israel,González, Carlos,Damha, Masad J.
supporting information, p. 471 - 477 (2017/12/15)
The possible role of DNA i-motif structures in telomere biology and in the transcriptional regulation of oncogene promoter regions is supported by several recent studies. Herein we investigate the effect of four cytidine nucleosides (and combinations thereof) on i-motif structure and stability, namely 2′-deoxycytidine (dC), 2′-deoxy-5-methyl-cytidine (5-Me-dC), 2′-deoxy-2′-fluoro-arabinocytidine (2′F-araC), and 2′-deoxy-2′-fluoro-5-methyl-arabinocytidine (5-Me-2′F-araC). The base pair 5-Me-2′F-araC:2′F-araC produced i-motifs with a pH1/2 (“pKa”) value that closely matches physiological pH (7.34±0.3). NMR analysis of the most stable telomeric sequence (HJ-2) at pH 7.0 indicated that the structure is stabilized by hybrid 5-Me-dC:2′F-araC hemiprotonated base pairs and therefore highlights the significance of the interplay between base and sugar modifications on the stability of i-motif structures.
5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
-
, (2008/06/13)
Pyrimidine nucleosides exhibiting anti-viral and anti-tumor effects have the formula STR1 wherein A is OR3, SR3, NR3 R4 or NHacyl wherein R3 and R4 are the same or different and are hydroge