78644-77-6

Basic information

• Product Name: N-(3-methylphenyl)pyridin-2-amine
• Synonyms: N-(3-methylphenyl)pyridin-2-amine
• CAS NO: 78644-77-6
• Molecular Weight: 184.241
• Mol File: 78644-77-6.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: N-(3-methylphenyl)pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-methylphenyl)pyridin-2-amine(78644-77-6)
• EPA Substance Registry System: N-(3-methylphenyl)pyridin-2-amine(78644-77-6)

Safety Data

• Hazardous Substances Data: 78644-77-6(Hazardous Substances Data)

Upstream product

• 504-29-0 2-aminopyridine 
• 4886-77-5 3-methylthioanisole 
• 625-95-6 3-Iodotoluene 
• 109-09-1 2-chloropyridine 
• 108-44-1 1-amino-3-methylbenzene 
• 17933-03-8 m-tolylboronic acid 
• 591-17-3 meta-bromotoluene 
• 109-04-6 2-bromo-pyridine 

Relevant articles and documents

T-BuXPhos: A highly efficient ligand for Buchwald-Hartwig coupling in water

An efficient and versatile 'green' catalytic system for the Buchwald-Hartwig cross-coupling reaction in water is reported. In an aqueous micellar medium, the combination of t-BuXPhos with [(cinnamyl)PdCl]2 showed excellent performance for coupling arylbromides or chlorides with a large set of amines, amides, ureas and carbamates. The method is functional-group tolerant, proceeds smoothly (30 to 50 °C) and provides rapid access to the target compounds in good to excellent isolated yields. When applied to the synthesis of a known NaV1.8 modulator, this method led to a significant improvement of the E-factor in comparison with classical organic synthesis. the Partner Organisations 2014.

Copper anchored on phosphorus g-C3N4as a highly efficient photocatalyst for the synthesis ofN-arylpyridin-2-amines

A heterogeneous photocatalyst based on copper modified phosphorus doped g-C3N4(Cu/P-CN) has been prepared and characterized. This recyclable catalyst exhibited high photocatalytic activity for the synthesis ofN-arylpyridin-2-amine derivatives by the reaction of 2-aminopyridine and aryl boronic acid at room temperature under the irradiation of blue light. Importantly, the range of substrates for this coupling reaction has been expanded to include aryl boronic acids with strong electron-withdrawing groups as viable raw materials. In addition, this heterogeneous catalyst can be used at least 6 times while maintaining its catalytic activity.

Palladium-Catalyzed Amination of Aryl Sulfides and Sulfoxides with Azaarylamines of Poor Nucleophilicity

The amination of aryl sulfides and sulfoxides with azaarylamines is investigated using a palladium-N-heterocyclic carbene (NHC) complex. Because azaarylamines are less nucleophilic than anilines, more reactive diaryl sulfides and sulfoxides are found to be suitable coupling partners that liberate better leaving arenethiolate or arenesulfenate anions, instead of aryl methyl sulfides as reported previously.