786593-06-4

Basic information

• Product Name: DEHYDROANDROGRAPHOLIDESUCCINATE
• Synonyms: DEHYDROANDROGRAPHOLIDESUCCINATE;14-Deoxy-11,12-didehydroandrographolide bis(hemisuccinate);Butanedioic acid 1-[[(1R,2R,4aR,5R,8aS)-2-(3-carboxy-1-oxopropoxy)-5-[(1E)-2-(2,5-dihydro-2-oxo-3-furanyl)ethenyl]decahydro-1,4a-dimethyl-6-methylene-1-naphthalenyl]methyl] ester;Dehydroandrographolide Succinat
• CAS NO: 786593-06-4
• Molecular Formula: C₂₈H₃₆O₁₀
• Molecular Weight: 532.582
• Mol File: 786593-06-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 136-138℃
• Boiling Point: 733.8 °C at 760 mmHg
• Flash Point: 239.1 °C
• Appearance: /
• Density: 1.29
• Vapor Pressure: 1.48E-23mmHg at 25°C
• Refractive Index: 1.562
• PKA: 4.41±0.17(Predicted)
• CAS DataBase Reference: DEHYDROANDROGRAPHOLIDESUCCINATE(CAS DataBase Reference)
• NIST Chemistry Reference: DEHYDROANDROGRAPHOLIDESUCCINATE(786593-06-4)
• EPA Substance Registry System: DEHYDROANDROGRAPHOLIDESUCCINATE(786593-06-4)

Safety Data

• Hazardous Substances Data: 786593-06-4(Hazardous Substances Data)

Usage

Description

Dehydroandrographolide Succinate, a compound derived from traditional Chinese medicine, is known for its potent anti-inflammatory and antimicrobial properties. It is primarily extracted from the plant Andrographis paniculata, which has been used for centuries in traditional medicine practices. DEHYDROANDROGRAPHOLIDESUCCINATE's unique structure and bioactive properties make it a valuable candidate for various therapeutic applications.

Uses

Used in Pharmaceutical Industry:
Dehydroandrographolide Succinate is used as an active pharmaceutical ingredient for its anti-inflammatory and antimicrobial properties. It is particularly effective in the treatment of pneumonia and respiratory tract infections, providing relief from symptoms and aiding in the recovery process.
Used in Traditional Chinese Medicine:
In the field of traditional Chinese medicine, Dehydroandrographolide Succinate is used as a key component in various herbal formulations. Its potent anti-inflammatory and antimicrobial actions make it a valuable addition to treatments for a wide range of conditions, including respiratory illnesses and other inflammatory disorders.
Used in Antiviral Applications:
Dehydroandrographolide Succinate has demonstrated antiviral properties, making it a potential candidate for the development of new antiviral drugs. Its ability to inhibit viral replication and reduce inflammation could be beneficial in the treatment of various viral infections, including influenza and other respiratory illnesses.
Used in Immunomodulatory Applications:
Due to its immunomodulatory effects, Dehydroandrographolide Succinate is being explored for its potential use in regulating the immune system. This could be particularly useful in conditions where the immune system is overactive or underactive, providing a means to restore balance and improve overall health.

InChI:InChI=1/C28H36O10/c1-17-4-7-20-27(2,19(17)6-5-18-13-15-36-26(18)35)14-12-21(38-25(34)11-9-23(31)32)28(20,3)16-37-24(33)10-8-22(29)30/h5-6,13,19-21H,1,4,7-12,14-16H2,2-3H3,(H,29,30)(H,31,32)/b6-5+/t19-,20+,21-,27+,28+/m1/s1

Upstream product

• 108-30-5 succinic acid anhydride 
• 142037-79-4 andrographolide 

Relevant articles and documents

Efficient acylation and one-pot synthesis of dehydroandrographolide succinate on a large scale assisted with microwave radiation

A rapid and convenient method for acylation and large-scale synthesis of dehydroandrographolide succinate has been developed under microwave irradiation. It is a one-pot condensation and is compatible with dehydration and rearrangement of double bond in mild reaction conditions with good yield, high purity (up to 99.8%), time-savings, few pollutants and low cost. In addition, a number of acylation derivatives were synthesized under microwave irradiation.