78686-87-0

Basic information

• Product Name: 2,5-DICHLOROPYRIDINE-3-CARBONYL CHLORIDE
• Synonyms: BUTTPARK 43\57-85;2,5-DICHLOROPYRIDINE-3-CARBONYL CHLORIDE;2,5-Dichloro-nicotinoyl chloride;3-(Chlorocarbonyl)-2,5-dichloropyridine, 2,5-Dichloropyridine-3-carbonyl chloride;2,5-dichloropyridin-3-carbonyl chloride
• CAS NO: 78686-87-0
• Molecular Formula: C₆H₂Cl₃NO
• Molecular Weight: 210.45
• Mol File: 78686-87-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 138 °C
• Flash Point: 116.5 °C
• Appearance: /
• Density: 1.582 g/cm³
• Vapor Pressure: 0.00745mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 2,5-DICHLOROPYRIDINE-3-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DICHLOROPYRIDINE-3-CARBONYL CHLORIDE(78686-87-0)
• EPA Substance Registry System: 2,5-DICHLOROPYRIDINE-3-CARBONYL CHLORIDE(78686-87-0)

Safety Data

• Hazard Codes: C,Xn
• Statements: 34-22
• Safety Statements: 26-36/37/39-45
• RIDADR: 3265
• HazardClass: IRRITANT
• Hazardous Substances Data: 78686-87-0(Hazardous Substances Data)

Usage

General Description

2,5-Dichloropyridine-3-carbonyl chloride is a chemical compound with the molecular formula C6H2Cl3NO. It is a derivative of pyridine and is used in various chemical reactions and processes as a reagent and intermediate. 2,5-DICHLOROPYRIDINE-3-CARBONYL CHLORIDE is commonly employed in the manufacture of pharmaceuticals, agrochemicals, and other fine chemicals. It is a potent electrophilic reagent due to the presence of a highly reactive carbonyl chloride group, which makes it valuable in synthetic organic chemistry for the formation of various carbon-carbon and carbon-heteroatom bonds. Additionally, this compound is known for its potential use in the creation of novel and complex molecular structures for further research and development purposes.

InChI:InChI=1/C6H2Cl3NO/c7-3-1-4(6(9)11)5(8)10-2-3/h1-2H

Upstream product

• 38076-80-1 5-chloro-2-hydroxypyridine-3-carboxylic acid 

Downstream Products

• 952152-77-1 (S)-N-((3-(3,5-difluoro-4-(2-chloro-10-oxo-5,6,8,9-tetrahydro-10H-4,4b,7,9a-tetraazabenzo[a]azulen-7-yl)-phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide 
• 75291-86-0 2,5-dichloropyridine-3-carboxamide 
• 1186376-03-3 2,5-dichloro-N-[4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide 
• 1265635-32-2 2,5-dichloro-N-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)nicotinamide 

Relevant articles and documents

Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems

Novel AT1 receptor antagonists bearing the pyrazolo[3,4-b] pyridine bicyclic heteroaromatic system (or structurally related moieties) were designed and synthesized as the final step of a large program devoted to the development of new antihypertensive agents and to the understanding of the molecular basis of their pharmacodynamic and pharmacokinetic properties. The preliminary pharmacological characterization revealed nanomolar AT1 receptor affinity for several compounds of the series and a potent antagonistic activity in isolated rabbit aortic strip functional assay for 7c and 8a. These results stimulated the study of the biopharmaceutical properties of some selected compounds, which were found to be characterized by a permeability from medium to high. Remarkably, the least permeable 7c showed both permeability and oral bioavailability (80%) higher than losartan, but its terminal half-life was shorter. These results suggest that the permeability is not a limiting factor in the pharmacokinetics of these AT1 receptor antagonists.