78703-53-4Relevant articles and documents
Synthesis method of 1, 3-dimethyl-1H-pyrazole-4-carboxylic acid
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, (2021/03/13)
The invention relates to a synthesis method of 1, 3-dimethyl-1H-pyrazole-4-carboxylic acid, and the method comprises the following steps: 1, carrying out condensation reaction on N, N-dimethylamino ethyl acrylate, triethylamine and acetyl chloride to generate ethyl 2-dimethylamino-3-oxobutyrate and triethylamine hydrochloride; 2, carrying out a cyclization reaction on 2-dimethylamino ethyl-3-oxobutyrate and methylhydrazine to generate 1, 3-dimethyl-1H-pyrazole ethyl-4-formate and a dimethylamine aqueous solution; 3, carrying out a reaction on formic acid, ethyl acetoacetate and dimethylamine generated in the step 2 cyclization reaction to generate 2-dimethylamino ethyl-3-oxobutyrate and water, wherein the ethyl 2-dimethylamino-3-oxobutyrate generated in the step 3 is recycled as a reactantin the step 2; 4, hydrolyzing the ethyl 1, 3-dimethyl-1H-pyrazole-4-formate to obtain the 1, 3-dimethyl-1H-pyrazole-4-carboxylic acid. The 1, 3-dimethyl-1H-pyrazole-4-carboxylic acid has the advantages of few synthesis steps, safe reaction process and no three-waste pollution, and is suitable for industrial batch large-scale preparation.
Method for synthesizing 1,3-dimethyl-1H-pyrazole-4-carboxylic acid
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Paragraph 0022; 0035; 0039-0041; 0058-0063, (2019/11/12)
The invention relates to a method for synthesizing 1,3-dimethyl-1H-pyrazole-4-carboxylic acid. The method comprises the step that 1,3-dimethyl-1H-pyrazole-4-carboxylic acid is prepared from the raw material: ethyl acetoacetate through condensation and ring closure, formylation, reductive dechlorination and oxidation. Compared with an existing method, the method has lower reaction cost, a higher yield and better economic performance; and the problems such as cost and environmental pollution caused by heavy metal oxidation are solved, and conditions are created for industrialization.
Application of 1,3-dimethyl-1H-pyrazole-4-amide derivatives to herbicide preparation
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Paragraph 0013; 0016; 0017, (2019/01/16)
The invention relates to an application of 1,3-dimethyl-1H-pyrazole-4-amide derivatives to herbicide preparation. Lettuce and Agrostis seeds are taken as test objects, and the following steps are carried out: sample treatment: the seeds are subjected to surface sterilization with 5%-10% Chlorox solution for 10 min before bioassay, and then the seeds are washed thoroughly by deionized water in a Millipore system and aired in an aseptic environment; sample treatment: 1 mM solutions are prepared from all samples by adopting acetone as a solvent; bioassay: bioassay is performed finally, and obtained compounds show better inhibition for lettuce and Agrostis. The compounds are new compounds with herbicidal activity, and the basis is provided for research and development of new pesticides.