78739-00-1

Basic information

• Product Name: Fulvicin
• Synonyms: NSC 41728;Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'R-trans)-
• CAS NO: 78739-00-1
• Molecular Formula: C₁₇H₁₇ClO₆
• Molecular Weight: 352.76628
• EINECS: 204-767-4
• Mol File: 78739-00-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 217-224℃
• Boiling Point: 527.9°C at 760 mmHg
• Flash Point: 205.9°C
• Appearance: /
• Density: 1.35g/cm³
• Vapor Pressure: 3.11E-11mmHg at 25°C
• Refractive Index: 1.565
• Water Solubility: practically insoluble
• CAS DataBase Reference: Fulvicin(CAS DataBase Reference)
• NIST Chemistry Reference: Fulvicin(78739-00-1)
• EPA Substance Registry System: Fulvicin(78739-00-1)

Safety Data

• Hazard Codes: T:Toxic
• Statements: R60:; R61:; R40:; R43:
• Safety Statements: S53:; S22:; S36/37/39:; S45:
• Hazardous Substances Data: 78739-00-1(Hazardous Substances Data)

Usage

General Description

Fulvicin is the brand name for the oral antifungal medication griseofulvin, which is used to treat various fungal infections, including ringworm, athlete's foot, and jock itch. It works by stopping the growth of fungi and is particularly effective against dermatophyte infections. Griseofulvin is classified as a fungistatic agent, meaning it prevents the growth and reproduction of fungi rather than directly killing them. It is typically prescribed as a course of treatment for several weeks or months, depending on the severity of the infection. Like all medications, Fulvicin may have potential side effects, including headache, nausea, vomiting, diarrhea, and allergic reactions, so it should only be used under the guidance of a healthcare professional. Regular monitoring by a healthcare provider is important to ensure the medication is effective and not causing any adverse effects.

InChI:InChI=1/C17H19ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h7-8,12H,5-6H2,1-4H3/t8-,12?,17+/m1/s1

Upstream product

• 186581-53-3 diazomethane 
• 469-53-4 (2R,6'R)-7-chloro-4,6-dimethoxy-6'-methyl-spiro[benzofuran-2,1'-cyclohexane]-3,2',4'-trione 
• 67-56-1 methanol 
• 141-52-6 sodium ethanolate 
• 126-07-8 griseofulvin 
• 124-41-4 sodium methylate 
• 7776-77-4 (+/-)-dehydrogriseofulvin 
• 3573-90-8 (-)-dehydrogriseofulvin 
• 132692-41-2 7-chloro-4,6-dimethoxy-2-<5-methoxy-1-(methylthio)-3-oxohexylidene>-3(2H)-benzofuranone 
• 26881-62-9 dl-2'-demethoxy-2'-(methylthio)griseofulvin 
• 132692-40-1 5-Methoxy-1,1-bis-methylsulfanyl-hex-1-en-3-one 
• 126-07-8 d,l-epigriseofulvin 
• 129529-56-2 (Z)-7-chloro-4,6-dimethoxy-2-(1-propylidene)-3(2H)-benzofuranone 
• 3261-06-1 7-chloro-4,6-dimethoxy-2,3-dihydrobenzofuran-3-one 

Downstream Products

• 126-07-8 griseofulvin 
• 126-07-8 griseofulvin 
• 17793-65-6 (-)-2'-demethoxy-2',3'-dihydroepigriseofulvin 

Relevant articles and documents

Syntheses and antifungal activity of dl-griseofulvin and its congeners. II

Griseofulvin derivatives, dl-6'-demethyl-6'-ethylgriseofulvin (dl-5) and dl-6'-demethyl-6'-phenylgriseofulvin (dl-6) were prepared by application of a synthetic method developed by us. Antifungal activity of these derivatives decreased in the order of dl-

An improved synthetic method for dl-griseofulvin and its 2'-s-analogue

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Microbial transformation of (+)- and (-)-2'-demethoxydehydrogriseofulvin by Streptomyces cinereocrocatus

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