78746-23-3

Basic information

• Product Name: Pro-Phe-OBn
• Synonyms: Pro-Phe-OBn
• CAS NO: 78746-23-3
• Molecular Weight: 352.433
• Mol File: 78746-23-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Pro-Phe-OBn(CAS DataBase Reference)
• NIST Chemistry Reference: Pro-Phe-OBn(78746-23-3)
• EPA Substance Registry System: Pro-Phe-OBn(78746-23-3)

Safety Data

• Hazardous Substances Data: 78746-23-3(Hazardous Substances Data)

Upstream product

• 2462-32-0 L-phenylalanine benzyl ester hydrochloride 
• 1738-78-9 L-phenylalanine benzyl ester p-toluene-sulfonic acid salt 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 71989-31-6 Fmoc-Pro-OH 
• 962-39-0 L-Phenylalanine benzyl ester 
• 188048-61-5 (S)-2-((S)-1-Benzyloxycarbonyl-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester 
• 74257-60-6 (S)-tert-butyl 2-((S)-1-(benzyloxy)-1-oxo-3-phenylpropan-2-ylcarbamoyl)pyrrolidine-1-carboxylate 

Downstream Products

• 220187-37-1 N-(2-Methoxycarbonylphenylsulfonyl)-L-prolyl-L-phenylalanine benzyl ester 
• 126706-69-2 C₆₆H₈₀N₈O₁₀ 
• 126706-67-0 (S)-2-{[(S)-1-((S)-3-(1-Benzyl-1H-imidazol-4-yl)-2-{(2S,3S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionic acid benzyl ester 
• 738550-99-7 (S)-2-({(S)-1-[(S)-2-{(2S,3S)-2-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(4-benzyloxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-3-(1-benzyl-1H-imidazol-4-yl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid benzyl ester 
• 759423-68-2 (S)-2-({(S)-1-[(S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(4-benzyloxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-3-(1-benzyl-1H-imidazol-4-yl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid benzyl ester 
• 126706-65-8 (S)-2-({(S)-1-[(S)-3-(1-Benzyl-1H-imidazol-4-yl)-2-((2S,3S)-2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid benzyl ester 
• 109068-26-0 (S)-2-({(S)-1-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-3-(1-benzyl-1H-imidazol-4-yl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid benzyl ester 
• 78746-26-6 (S)-2-({(S)-1-[(S)-2-Amino-3-(1-benzyl-1H-imidazol-4-yl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid benzyl ester 
• 129988-00-7 (S)-2-[((S)-1-Methoxyoxalyl-pyrrolidine-2-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester 
• 78746-24-4 N-Boc-L-(benzyl)histidyl-L-prolyl-L-phenylalanine benzyl ester 

Relevant articles and documents

Total Synthesis of Gombamide A

The first total synthesis of Gombamide A (1), a cytotoxic cyclic thiopeptide from the sponge Clathria gombawuiensis, has been achieved. Highlights of the convergent synthesis feature a disulfide bond forming cascade to close the 17-membered macrocycle and a selenoazidylation procedure to access the unusual para-hydroxystyrlyamide (pHSA) moiety. The synthesis required 18 steps, 11 steps in its longest linear sequence, and proceeded in 9.1% overall yield. This work will facilitate the study of the biological effects of Gombamide A and provide groundwork to explore the structure-activity relationship around this rare natural product.

Rapid peptide synthesis in liquid phase. Preparation of angiotensin II and delta-sleep-inducing peptide by the 'hold-in' solution method

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