787554-04-5 Usage
Description
NALPHA-(2,4,6-TRIISOPROPYLBENZENESULFONYL)-O-(TERT-BUTYLDIPHENYLSILYL)-PROS-METHYL-L-HISTIDINOL, with the CAS number 787554-04-5, is a complex histidine-derived compound characterized by its unique chemical structure. This structure endows it with specific properties that make it suitable for various applications, particularly in the field of catalysis.
Uses
Used in Chemical Synthesis:
NALPHA-(2,4,6-TRIISOPROPYLBENZENESULFONYL)-O-(TERT-BUTYLDIPHENYLSILYL)-PROS-METHYL-L-HISTIDINOL is used as a catalyst in enantioselective esterification. Its application in this process is crucial for the production of optically active compounds, which are essential in the pharmaceutical industry for the development of drugs with specific biological activities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, NALPHA-(2,4,6-TRIISOPROPYLBENZENESULFONYL)-O-(TERT-BUTYLDIPHENYLSILYL)-PROS-METHYL-L-HISTIDINOL is used as a key intermediate in the synthesis of various chiral drugs. Its ability to facilitate enantioselective reactions contributes to the production of high-quality, single-enantiomer pharmaceuticals, which are vital for ensuring the safety and efficacy of medications.
Used in Research and Development:
NALPHA-(2,4,6-TRIISOPROPYLBENZENESULFONYL)-O-(TERT-BUTYLDIPHENYLSILYL)-PROS-METHYL-L-HISTIDINOL also plays a significant role in research and development, particularly in the field of asymmetric catalysis. Its unique properties make it an invaluable tool for chemists working on the development of new, more efficient, and selective catalytic systems for various chemical transformations.
Check Digit Verification of cas no
The CAS Registry Mumber 787554-04-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,8,7,5,5 and 4 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 787554-04:
(8*7)+(7*8)+(6*7)+(5*5)+(4*5)+(3*4)+(2*0)+(1*4)=215
215 % 10 = 5
So 787554-04-5 is a valid CAS Registry Number.
InChI:InChI=1/C38H53N3O3SSi/c1-27(2)30-21-35(28(3)4)37(36(22-30)29(5)6)45(42,43)40-31(23-32-24-39-26-41(32)10)25-44-46(38(7,8)9,33-17-13-11-14-18-33)34-19-15-12-16-20-34/h11-22,24,26-29,31,40H,23,25H2,1-10H3/t31-/m0/s1
787554-04-5Relevant articles and documents
Kinetic resolution of racemic alcohols catalyzed by minimal artificial acylases derived from l-histidine
Kosugi, Yuji,Akakura, Matsujiro,Ishihara, Kazuaki
, p. 6191 - 6203 (2008/02/05)
The artificial acylases, tert-butyldiphenylsilyl ether and tris(trimethylsilyl)silyl ether of N(π)-methyl-N(α)-(2,4,6-triisopropylbenzenesulfonyl)-l-histidinol, are simple and small molecules, which contain only one chiral carbon center that originates from natural l-histidine. Asymmetric acylation of racemic secondary alcohols with isobutyric anhydride induced by these artificial acylases gave optically active isobutyrates and optically active alcohols with an S(kfast-reacting enantiomer/kslow-reacting enantiomer) value of up to 132. One hydrogen bonding interaction between a sulfonamidyl group of the catalysts and a substrate should be essential for inducing the high level of kinetic resolution through catalytic asymmetric acylation. Furthermore, a reusable polystyrene-bound artificial acylase was developed to examine its practicality.
