787640-37-3

Basic information

• Product Name: 2-Oxa-5-azabicyclo[2.2.1]heptane-5-carboxylic acid, phenylmethyl ester, (1R,4R)-
• CAS NO: 787640-37-3
• Molecular Weight: 233.267
• Mol File: 787640-37-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Oxa-5-azabicyclo[2.2.1]heptane-5-carboxylic acid, phenylmethyl ester, (1R,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxa-5-azabicyclo[2.2.1]heptane-5-carboxylic acid, phenylmethyl ester, (1R,4R)-(787640-37-3)
• EPA Substance Registry System: 2-Oxa-5-azabicyclo[2.2.1]heptane-5-carboxylic acid, phenylmethyl ester, (1R,4R)-(787640-37-3)

Safety Data

• Hazardous Substances Data: 787640-37-3(Hazardous Substances Data)

Upstream product

• 444313-67-1 (1R,4R)-5-acetyl-2-oxa-5-azabicyclo[2.2.1]heptan-3-one 
• 77449-94-6 (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride 
• 114676-59-4 (2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride 
• 155075-23-3 (2R,4R)-1-benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 787640-34-0 (2R,4R)-1-benzyl 2-methyl 4-((tert-butyldimethylsilyl)oxy)pyrrolidine-1,2-dicarboxylate 
• 787640-35-1 (2R,4R)-benzyl 4-((tert-butyldimethylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 51-35-4 4R-4-hydroxyproline 
• 36901-86-7 cis-hydroxy-D-proline 
• 787640-36-2 (2R,4R)-benzyl 4-(tert-butyldimethylsilyloxy)-2-((methylsulfonyloxy)methyl)pyrrolidine-1-carboxylate 

Downstream Products

• 661470-56-0 (1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane 

Relevant articles and documents

PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF

The present invention relates to phenyl amino pyrimidine bicyclic compounds formula (I) which are inhibitors of protein kinases including JAK kinases. In particular the compounds are active against JAK1, JAK2, JAK3 and TYK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

HETEROCYCLIC CYCLOPENTYL TETRAHYDROISOQUINOLINE AND TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present invention is directed to compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.