78840-04-7Relevant articles and documents
Photoinduced DNA Interstrand Cross-Linking by Benzene Derivatives: Leaving Groups Determine the Efficiency of the Cross-Linker
Fan, Heli,Peng, Xiaohua
, p. 493 - 506 (2020/12/22)
We have synthesized and characterized two small libraries of 2-OMe or 2-NO2-benzene analogues 2a-i and 3a-i containing a wide variety of leaving groups. Irradiation of these compounds at 350 nm generated benzyl radicals that were spontaneously oxidized to
Studies on the total synthesis of lactonamycin: Synthesis of the CDEF ring system
Wehlan, Hermut,Jezek, Eva,Lebrasseur, Nathalie,Pave, Gregoire,Roulland, Emmanuel,White, Andrew J. P.,Burrows, Jeremy N.,Barrett, Anthony G. M.
, p. 8151 - 8158 (2007/10/03)
A concise and efficient synthesis of the tetracyclic CDEF ring system of lactonamycin (1) is described. The key step involved the Lewis acid mediated, intramolecular Friedel-Crafts acylation of carboxylic acid 6 to produce the tetracyclic CDEF core struct
Bis(bioreductive) alkylating agents: Synthesis and biological activity in a nude mouse human carcinoma model
Witiak, Donald T.,Kamat, Prabhakar L.,Allison, Debra L.,Liebowitz, Stephen M.,Glaser, Ronald,et al.
, p. 1679 - 1686 (2007/10/02)
Chemical investigations leading to the construction of bis(bioreductive) alkylating agents having both conformationally restricted and mobile spacer regions are described. Two targets having the conformationally mobile ethylene spacer group, namely, 2,2'-ethylenebis[6-(hydroxymethyl)-p-benzoquinone] diacetate (3b) and 2,2'-ethylenebis[6-(bromomethyl)-p-benzoquinone] (3c), were studied in vivo and in vitro using an established epithelial/Burkitt lymphoma hybrid cell line (D98/HR1) previously shown to induce carcinomas in nude mice. Inactivity of both test compounds in vitro, the relative resistance of these cells to test drugs in vitro, and the selective antitumor properties of the bis(bromomethyl) analogue in vivo lead to the proposal that this compound undergoes bioreduction to an alkylating species in the hypoxic core of the tumor, thereby exerting its action.