788824-75-9

Basic information

• Product Name: Carbamic acid, [2-[4-[(4-fluorophenyl)methoxy]phenyl]ethyl]-, 1,1-dimethylethyl ester
• CAS NO: 788824-75-9
• Molecular Formula: C20H24FNO3
• Molecular Weight: 345.414
• Mol File: 788824-75-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-[4-[(4-fluorophenyl)methoxy]phenyl]ethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-[4-[(4-fluorophenyl)methoxy]phenyl]ethyl]-, 1,1-dimethylethyl ester(788824-75-9)
• EPA Substance Registry System: Carbamic acid, [2-[4-[(4-fluorophenyl)methoxy]phenyl]ethyl]-, 1,1-dimethylethyl ester(788824-75-9)

Safety Data

• Hazardous Substances Data: 788824-75-9(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 51-67-2 tyrosamine 
• 64318-28-1 N-t-butoxycarbonyl-tyramine 
• 459-46-1 4-Fluorobenzyl bromide 

Relevant articles and documents

Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection

Due to the increased morbidity and mortality by fungal infections and the emergence of severe antifungal resistance, there is an urgent need for new antifungal agents. Here, we screened for antifungal activity in our in-house library through the minimum inhibitory concentration test and derived two hit compounds with moderate antifungal activities. The hit compounds' antifungal activities and drug-like properties were optimized by substituting various aryl ring, alkyl chain, and methyl groups. Among the optimized compounds, 22h was the most promising candidate with good drug-like properties and exhibited potent fast-acting fungicidal antifungal effects against various fungal pathogens and synergistic antifungal activities with some known antifungal drugs. Additionally, 22h was further confirmed to disturb fungal cell wall integrity by activating multiple cell wall integrity pathways. Furthermore, 22h exerted significant antifungal efficacy in both the subcutaneous infection mouse model and ex vivo human nail infection model.

Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy

Benzyloxyphenyl moiety is a common structure of highly potent, selective and reversible inhibitors of monoamine oxidase B (MAO-B), safinamide and sembragiline. We synthesized 4-(benzyloxy)phenyl and biphenyl-4-yl derivatives including halogen substituents on the terminal aryl unit. In addition, we modified the carbon linker between amine group and the biaryl linked unit. Among synthesized compounds, 12c exhibited the most potent and selective MAO-B inhibitory effect (hMAO-B IC50: 8.9 nM; >10,000-fold selectivity over MAO-A) as a competitive inhibitor. In addition, 12c showed greater MAO-B inhibitory activity and selectivity compared to well-known MAO-B inhibitors such as selegiline, safinamide and sembragiline. In the MPTP-induced mouse model of Parkinson's disease (PD), 12c significantly protected the tyrosine hydroxylase (TH)-immunopositive DAergic neurons and attenuated the PD-associated behavioral deficits. This study suggests characteristic structures as a MAO-B inhibitor that may provide a good insight for the development of therapeutic agents for PD.