78908-26-6

Basic information

• Product Name: (E)-7-[(1S,2S,3S)-3-Hydroxy-2-((E)-4-hydroxy-4-methyl-oct-1-enyl)-5-oxo-cyclopentyl]-hept-4-enoic acid methyl ester
• CAS NO: 78908-26-6
• Molecular Weight: 380.525
• Mol File: 78908-26-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-7-[(1S,2S,3S)-3-Hydroxy-2-((E)-4-hydroxy-4-methyl-oct-1-enyl)-5-oxo-cyclopentyl]-hept-4-enoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-7-[(1S,2S,3S)-3-Hydroxy-2-((E)-4-hydroxy-4-methyl-oct-1-enyl)-5-oxo-cyclopentyl]-hept-4-enoic acid methyl ester(78908-26-6)
• EPA Substance Registry System: (E)-7-[(1S,2S,3S)-3-Hydroxy-2-((E)-4-hydroxy-4-methyl-oct-1-enyl)-5-oxo-cyclopentyl]-hept-4-enoic acid methyl ester(78908-26-6)

Safety Data

• Hazardous Substances Data: 78908-26-6(Hazardous Substances Data)

Upstream product

• 85168-46-3 (+/-)-methyl 7-(4-hydroxy-2-methoxy-5-oxo-1-cyclopenten-1-yl)-4(E)-heptenoate 
• 85168-49-6 4R(+)-hydroxy-2-(6-methoxycarbonyl-3-cis-hexenyl)-2-cyclopentenone 
• 66792-29-8 (E)-1-(tri-n-butylstannyl)-4-methyl-4-<(trimethylsilyl)-oxy>-1-octene 
• 85168-37-2 (E)-7-(5-Oxo-3-triethylsilanyloxy-cyclopent-1-enyl)-hept-4-enoic acid methyl ester 

Relevant articles and documents

Synthesis and gastric antisecretory properties of 4,5-unsaturated derivatives of 15-deoxy-16-hydroxy-16-methylprostaglandin E1

The synthesis and gastric antisecretory activities of the Δ4,5-cis, Δ4,5-trans, and 4,5-acetylenic analogues of 15-deoxy-16-hydroxy-16-methyl prostaglandin E1 methyl ester are described. The key step in the preparation of these compounds involved the stereospecific conjugate addition of a cuprate reagent to the appropriate cyclopentenones. Although the trans and acetylenic derivatives were weak inhibitors of gastric acid secretion, the cis olefin was more potent and longer acting than the saturated parent compound. Selectivity with respect to unwanted diarrheagenic effects was found to be improved over that of both the parent 16-hydroxy compound and the reference standards, (15S)-15-methyl- and 16,16-dimethylprostaglandin E2.