78950-30-8

Basic information

• Product Name: Benzenecarbothioamide, 4-cyano-
• CAS NO: 78950-30-8
• Molecular Formula: C8H6N2S
• Molecular Weight: 162.215
• Mol File: 78950-30-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenecarbothioamide, 4-cyano-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarbothioamide, 4-cyano-(78950-30-8)
• EPA Substance Registry System: Benzenecarbothioamide, 4-cyano-(78950-30-8)

Safety Data

• Hazardous Substances Data: 78950-30-8(Hazardous Substances Data)

Upstream product

• 623-26-7 terephthalonitrile 
• 26197-93-3 p-bromothiobanzamide 
• 3034-34-2 4-cyanobenzamide 

Downstream Products

• 4989-36-0 4-thiocarbamoylbenzoic acid 
• 1620320-76-4 C₁₇H₉N₃O₂S 
• 1334212-49-5 4,4'-(1,2,4-thiadiazole-3,5-diyl)dibenzonitrile 
• 873009-61-1 C₁₁H₇ClN₂S 

Relevant articles and documents

A efficient protocol for the synthesis of thioamides in [DBUH][OAc] at room temperature

A novel, simple and eco-friendly method to synthesize thioamides from aryl nitriles and sodium sulfide (Na2S·9H2O) catalyzed by 1,8-diazabicyclo[5,4,0]undec-7-enium acetate ([DBUH][OAc]) ionic liquid (IL) at room temperature was developed in this paper. In this reaction, readily available inorganic salt (Na2S·9H2O) serves as the sulfur source, and various functional groups of aryl nitriles were well tolerated at room temperature. In addition, the products were easily separated from the IL which could be reused at least five times without considerable loss of its activity and applied in the green, concise synthesis of ethionamide.

Heterocycle-bridged and conformationally constrained retinoids: Synthesis of 4-(7,8,9,10-Tetrahydro-7,7,10,10-tetramethyl-4H-benzo[6,7]chromeno-[4,3-d]thiazole-2-yl)benzoic acid

Retinoids are a class of synthetic and natural compounds structurally related to retinoic acid. In a search for discovery of a new class of heterocycle-bridged and conformationally constrained retinoids, here we report the synthesis of 4-(7,8,9,10-tetrahydro-7,7,10,10-tetramethyl-4H-benzo[6,7]chromeno[4,3-d]thiazole-2-yl)benzoic acid (10) starting from 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalen-2-ol (13). Several approaches was attempted to obtain target compound 10. Structure elucidation of synthesized compounds has been made on the basis of elemental analysis and spectral data (1H NMR, IR and MS).

FACTOR XA INHIBITORS

The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.