79016-11-8

Basic information

• Product Name: ethyl 2-(1-bromo-2-ethoxy-2-oxoethyl)benzoate
• Synonyms: ethyl 2-(1-bromo-2-ethoxy-2-oxoethyl)benzoate
• CAS NO: 79016-11-8
• Molecular Weight: 315.164
• Mol File: 79016-11-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: ethyl 2-(1-bromo-2-ethoxy-2-oxoethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(1-bromo-2-ethoxy-2-oxoethyl)benzoate(79016-11-8)
• EPA Substance Registry System: ethyl 2-(1-bromo-2-ethoxy-2-oxoethyl)benzoate(79016-11-8)

Safety Data

• Hazardous Substances Data: 79016-11-8(Hazardous Substances Data)

Upstream product

• 89-51-0 Homophthalic acid 
• 14961-34-3 diethyl homophthalate 

Downstream Products

• 1350468-90-4 ethyl 1R-({2-[3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate 
• 1350469-23-6 ethyl (1R)-1-({2-[3-(dimethylcarbamoyl)-4-nitrophenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate 
• 1350469-24-7 ethyl (1R)-1-({2-[4-amino-3-(dimethylcarbamoyl)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate 
• 1350469-22-5 ethyl-(R)-1-((2-(3-(dimethylcarbamoyl)-4-(6-methyl-4′-(trifluoromethyl)-[1,1′-biphenyl]-2-carboxamido)phenyl)-acetoxy)methyl)-2-methylisoindoline-1-carboxylate 
• 1350469-25-8 ethyl (1R)-1-({2-[3-(dimethylcarbamoyl)-4-{[(4'-isopropoxybiphenyl-2-yl)carbonyl]amino}phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate 
• 1350468-64-2 (+/-)-benzyl 2-methyl-3-oxoisoindoline-1-carboxylate 
• 1350468-61-9 (+/-)-benzyl 1-(hydroxymethyl)-2-methyl-3-oxoisoindoline-1-carboxylate 
• 1198116-49-2 3-oxo-2-(2-pyridin-2-ylethyl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-1H-isoindole-1-carboxamide 
• 1065329-91-0 N-((2,4-dichlorophenyl)methyl)-2-ethyl-3-oxo-2,3-dihydro-1H-isoindole-1-carboxamide 

Relevant articles and documents

Aza-heterocyclic frameworks through intramolecular π-system trapping of spiro-N-acyliminiums generated from isoindolinone

Spiro-acetoxylactams as key substrates were obtained straightforwardly by the tandem regioselective reduction/O-acylation of spiro-isoindolinone-imides. The latter were produced in large scale in three steps from homophthalic acid. These imides were useful to provide in one step isoindolinones bearing hydroxymethyl-amide functions, tethered at quaternary carbon centre with promising biological issues. Submitted to Br?nsted (TFA neat) and Lewis acid (trimethylsilyltrifluoro-methanesulfonic (TMSOTf) 10 mol%), the spiro-acetoxylactams undergo π-cyclization of spiro-N-acyliminiums to provide diastereoselectively with π-aromatic original pyrrolopyrido- and pyrroloazepino-isoindoles fused or not to aromatic systems. With π-olefins, pyrrolopyridines and pyrrolo-azepines fused to isoindoline or containing amino-acids were isolated. A reaction mechanism producing all these systems is also discussed.

2-PHENYL BENZOYLAMIDES

Compounds of Formula I that inhibit microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (Apo B) secretion and their uses in the treatment of diseases linked thereto in animals are described herein.

Halolactonization of γ-acetylenic acids: systhesis of novel spiroisoindole halobutyrolactones

γ-Acetylenic carboxylic acids are cyclized to spirohalo butyrolactones, in the presence of NBS or NIS and K2CO3. The corresponding 5(E)-haloalkylidene-spirobutyrolactones were isolated in high yields, and this process constitutes an easy and efficient route to analogous structures of natural products of biological interest.