79050-23-0 Usage
Description
9Z,12Z-OCTADECADIENOIC-9,10,12,13-D4 ACID, also known as Linoleic Acid-d4, is a deuterated form of linoleic acid containing four deuterium atoms at the 9, 10, 12, and 13 positions. It is a polyunsaturated fatty acid (PUFA) found in plant tissues and most cooking oils. Linoleic acid is an essential fatty acid, and its deficiencies are linked to various health issues such as coronary heart disease, growth retardation, and allergies.
Uses
Used in Mass Spectrometry:
9Z,12Z-OCTADECADIENOIC-9,10,12,13-D4 ACID is used as an internal standard for the quantification of linoleic acid by gas chromatography (GC) or liquid chromatography (LC) mass spectrometry. This helps in accurately measuring the levels of linoleic acid in various samples.
Used in Pharmaceutical Industry:
9Z,12Z-OCTADECADIENOIC-9,10,12,13-D4 ACID is used as a labeled activator of peroxisome proliferator-activated receptors (PPAR). PPARs are a group of nuclear receptors that play a crucial role in regulating cellular differentiation, development, and metabolism. Linoleic Acid-d4 helps in studying the activation and function of PPARs, which can be useful in developing drugs targeting these receptors for treating various diseases.
Used in Research:
9Z,12Z-OCTADECADIENOIC-9,10,12,13-D4 ACID is used in research to study the metabolism of linoleic acid. Linoleic acid can be metabolized by prostaglandin H synthases (PGHS) to form 9and 13-HODE. The enzyme kinetics of PGHS-1 and PGHS-2 can be studied using Linoleic Acid-d4, with a Km of 12 μM for human PGHS-1 and 27 μM for PGHS-2. This information is valuable for understanding the role of linoleic acid in various biological processes and its potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 79050-23-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,0,5 and 0 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 79050-23:
(7*7)+(6*9)+(5*0)+(4*5)+(3*0)+(2*2)+(1*3)=130
130 % 10 = 0
So 79050-23-0 is a valid CAS Registry Number.
79050-23-0Relevant articles and documents
Synthesis of linoleic acids combinatorially labeled at the vinylic positions as substrates for lipoxygenases
Meyer, Matthew P.,Klinman, Judith P.
, p. 3600 - 3603 (2008/09/19)
Mammalian lipoxygenases have been implicated in a number of inflammation-related human diseases. Soybean lipoxygenase-1 is the archetypical example of known lipoxygenases. Here we report the synthesis of linoleic acid and (11,11)-d2-linoleic acid which are combinatorially labeled at the vinylic positions (9, 10, 12, and 13). Combinatorial labeling schemes allow for the simultaneous determination of KIEs in enzymatic reactions using NMR. Substrates are, thus, available as probes of detailed mechanism in kinetic isotope effect (KIE) studies of lipoxygenases.
