79054-11-8

Basic information

• Product Name: 2(3H)-Furanone, 5-(bromomethylene)dihydro-3-phenyl-, (E)-
• CAS NO: 79054-11-8
• Molecular Formula: C11H9BrO2
• Molecular Weight: 253.095
• Mol File: 79054-11-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2(3H)-Furanone, 5-(bromomethylene)dihydro-3-phenyl-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Furanone, 5-(bromomethylene)dihydro-3-phenyl-, (E)-(79054-11-8)
• EPA Substance Registry System: 2(3H)-Furanone, 5-(bromomethylene)dihydro-3-phenyl-, (E)-(79054-11-8)

Safety Data

• Hazardous Substances Data: 79054-11-8(Hazardous Substances Data)

Upstream product

• 79054-13-0 3-phenyl-5(Z)-trimethylsilylmethylidenetetrahydro-2-furanone 
• 103-82-2 phenylacetic acid 
• 79054-19-6 2-phenyl-5-trimethylsilyl-4-pentynoic acid 
• 79054-12-9 3-phenyl-5(E)-chloromercuriomethylidenetetrahydro-2-furanone 
• 51632-38-3 2-phenyl-pent-4-ynoic acid 

Relevant articles and documents

Design, synthesis, and structure-activity relationships of haloenol lactones: Site-directed and isozyme-selective glutathione S-transferase inhibitors

Overexpression of glutathione S-transferase (GST), particularly the GST-π isozyme, has been proposed to be one of the biochemical mechanisms responsible for drug resistance in cancer chemotherapy, and inhibition of overexpressed GST has been suggested as an approach to combat GST-induced drug resistance. 3-Cinnamyl-5(E)-bromomethylidenetetrahydro-2-furanone (1a), a lead compound of site-directed GST-π inactivator, has been shown to potentiate the cytotoxic effect of cisplatin on tumor cells. As an initial step to develop more potent and more selective haloenol lactone inactivators of GST-π, we examined the relationship between the chemical structures of haloenol lactone derivatives and their GST inhibitory activity. A total of 16 haloenol lactone derivatives were synthesized to probe the effects of (1) halogen electronegativity, (2) electron density of aromatic rings, (3) molecular size and rigidity, (4) lipophilicity, and (5) aromaticity on the potency of GST-π inactivation. The inhibitory potency of each compound was determined by time-dependent inhibition tests, and recombinant human GST-π was used to determine their inhibitory activity. Our structure-activity relationship studies demonstrated that (1) reactivity of the halide leaving group plays a weak role in GST inactivation by the haloenol lactones, (2) aromatic electron density may have some influence on the potency of GST inactivation, (3) high rigidity likely disfavors enzyme inhibition, (4) lipophilicity is inversely proportional to enzyme inactivation, and (5) an unsaturated system may be important for enzyme inhibition. This work facilitated understanding of the interaction of GST-π with haloenol lactone derivatives as site-directed and isozyme-selective inactivators, possibly potentiating cancer chemotherapy.