790667-68-4

Basic information

• Product Name: 1-BOC-4-(3-AMINOPHENOXY)PIPERIDINE
• Synonyms: 1-BOC-4-(3-AMINOPHENOXY)PIPERIDINE;tert-butyl 4-(3-aminophenoxy)piperidine-1-carboxylate;4-(3-Aminophenoxy)piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 790667-68-4
• Molecular Formula: C₁₆H₂₄N₂O₃
• Molecular Weight: 292.377
• Mol File: 790667-68-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BOC-4-(3-AMINOPHENOXY)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-(3-AMINOPHENOXY)PIPERIDINE(790667-68-4)
• EPA Substance Registry System: 1-BOC-4-(3-AMINOPHENOXY)PIPERIDINE(790667-68-4)

Safety Data

• Hazardous Substances Data: 790667-68-4(Hazardous Substances Data)

Usage

Molecular Weight

309.41 g/mol

Structure

Piperidine derivative with a BOC (tert-butoxycarbonyl) protecting group and an aminophenoxy moiety

Usage

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Physical State

White to off-white solid

Solubility

Soluble in organic solvents such as methanol, ethanol, and dichloromethane

Significance

Role in medicinal chemistry research, particularly in the development of new drugs and potential therapeutic agents

Upstream product

• 118811-07-7 tert-butyl 4-(tosyloxy)piperidin-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 554-84-7 meta-nitrophenol 
• 586412-88-6 tert-butyl-4-(3-nitrophenoxy)piperidine-1-carboxylate 
• 790667-69-5 4-(3-benzhydrylideneaminophenoxy)piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 790668-62-1 4-[3-(2-chloro-4-fluorobenzoylamino)phenoxy]piperidine-1-carboxylic acid tert-butyl ester 
• 871032-54-1 6-methyl-N-[3-(4-piperidinyloxy)phenyl]-4'-(trifluoromethoxy)-[1,1'-biphenyl]-2-carboxamide 
• 1364304-91-5 4-[3-(2-chloro-6-fluorobenzoylamino)phenoxy]piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

ISOINDOLINONE COMPOUNDS

Disclosed herein is a compound or pharmaceutically acceptable salts or stereoisomers thereof of of formula I wherein X1 is linear or branched C1-6 alkyl, C3-6 cycloalkyl, -C1-6 alkyl C3-6 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C1-6 alkyl C6-10 aryl, C1-6 alkyl 5-10 membered heteroaryl, wherein X1 is unsubstituted or substituted with one or more of halogen, linear or branched C1-6 alkyl, linear or branched C1-6 heteroalkyl, CF3, CHF2, -O-CHF2, -O-(CH2)2-OMe, OCF3, C1-6 alkylamino, -CN, -N(H)C(O)-C1- 6alkyl, -OC(O)-C1-6alkyl, -OC(O)-C1-4alkylamino, -C(O)O-C1-6alkyl, -COOH, - CHO, -C1-6alkylC(O)OH, -C1-6alkylC(O)O-C1-6alkyl, NH2, C1-6 alkoxy or C1-6 alkylhydroxy; X2 is hydrogen, C6-10 aryl, 5-10 membered heteroaryl, -O-(5-10 membered heteroaryl), 4-8 membered heterocycloalkyl, C1-4 alkyl 4-8 membered heterocycloalkyl, -O-(4-8 membered heterocycloalkyl), -O-C1-4 alkyl-(4-8 membered heterocycloalkyl), -OC(O)-C1-4alkyl-4-8 membered heterocycloalkyl or C6 aryloxy, wherein X2 is unsubstituted or substituted with one or more of linear or branched C1-6 alkyl, NH2, NMe2 or 5-6 membered heterocycloalkyl; n is 0, 1 or 2.

Substituted aminopyrimidine derivative, preparation method therefor and pharmaceutical application thereof

The invention relates to a substituted aminopyrimidine derivative as shown in general formula (I) and (II), an optical isomer, a pharmaceutically acceptable salt or co-crystallization thereof, a preparation method and application in preparation of tumor m

Discovery of N-(3-((1-Isonicotinoylpiperidin-4-yl)oxy)-4-methylphenyl)-3-(trifluoromethyl)benzamide (CHMFL-KIT-110) as a Selective, Potent, and Orally Available Type II c-KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs)

c-KIT kinase is a validated drug discovery target for gastrointestinal stromal tumors (GISTs). Clinically used c-KIT kinase inhibitors, i.e., Imatinib and Sunitinib, bear other important targets such as ABL or FLT3 kinases. Here we report our discovery of