790703-40-1

Basic information

• Product Name: Carbamic acid, [3-fluoro-4-(phenylmethoxy)phenyl]-, phenylmethyl ester
• CAS NO: 790703-40-1
• Molecular Formula: C21H18FNO3
• Molecular Weight: 351.377
• Mol File: 790703-40-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [3-fluoro-4-(phenylmethoxy)phenyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [3-fluoro-4-(phenylmethoxy)phenyl]-, phenylmethyl ester(790703-40-1)
• EPA Substance Registry System: Carbamic acid, [3-fluoro-4-(phenylmethoxy)phenyl]-, phenylmethyl ester(790703-40-1)

Safety Data

• Hazardous Substances Data: 790703-40-1(Hazardous Substances Data)

Upstream product

• 76243-24-8 1-(benzyloxy)-2-fluoro-4-nitrobenzene 
• 100-51-6 benzyl alcohol 
• 369-34-6 3,4-difluoronitrobenzene 
• 100-39-0 benzyl bromide 
• 403-19-0 2-fluoro-4-nitrophenol 
• 501-53-1 benzyl chloroformate 
• 168268-00-6 4-(benzyloxy)-3-fluoroaniline 

Downstream Products

• 790703-49-0 (R)-3-(4-benzyloxy-3-fluoro-phenyl)-5-(hydroxymethyl)-oxazolidin-2-one 
• 1025097-50-0 (R)‐3‐(3‐fluoro‐4‐hydroxyphenyl)‐5‐(hydroxymethyl)oxazolidin‐2‐one 
• 1025097-53-3 4-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-4-hydroxy-piperidine-1-carboxylic acid benzyl ester 
• 1025097-55-5 (R)-3-[3-fluoro-4-(4-hydroxypiperidin-4-ylmethoxy)phenyl]-5-hydroxymethyloxazolidin-2-one 

Relevant articles and documents

Synthesis, antibacterial activities, mode of action and acute toxicity studies of new oxazolidinone-fluoroquinolone hybrids

To combat bacterial resistance, a series of new oxazolidinone-fluoroquinolone hybrids have been synthesized and characterized. All synthetic hybrids were preliminarily evaluated for their in vitro antibacterial activities against 6 standard strains and 3 clinical isolates. The majority of hybrids displayed excellent activities against Gram-positive bacteria, but limited activities against Gram-negative bacteria. Hybrids OBP-4 and OBP-5 were found to be the most promising compounds. Further, in vitro antibacterial activities, mode of action and acute toxicity in mice of hybrids OBP-4 and OBP-5 were investigated. Hybrids OBP-4 and OBP-5 exhibited potent activities against Gram-positive bacteria, including drug-resistant strains. Correspondingly, studies on the mode of action of hybrids OBP-4 and OBP-5 indicated a strong inhibitory activity on protein synthesis by binding the active site of 50S subunit, but a weak inhibitory action on DNA synthesis. In addition, LD50 values of hybrids OBP-4 and OBP-5 in the acute oral toxicity were larger than 2000 mg/kg, suggesting a good safety profile.

Oxazolidinone-quinolone hybrid antibiotics

The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria: