79074-03-6

Basic information

• Product Name: 2-(benzyloxycarbonylamino)-4-hydroxybutanoic acid
• Synonyms: 2-(benzyloxycarbonylamino)-4-hydroxybutanoic acid
• CAS NO: 79074-03-6
• Molecular Weight: 253.255
• Mol File: 79074-03-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(benzyloxycarbonylamino)-4-hydroxybutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzyloxycarbonylamino)-4-hydroxybutanoic acid(79074-03-6)
• EPA Substance Registry System: 2-(benzyloxycarbonylamino)-4-hydroxybutanoic acid(79074-03-6)

Safety Data

• Hazardous Substances Data: 79074-03-6(Hazardous Substances Data)

Usage

Description

2-(benzyloxycarbonylamino)-4-hydroxybutanoic acid, also known as Z-Arg-OH, is a versatile compound that contains an amino acid and a benzyloxycarbonyl group. It is widely used as a building block in peptide synthesis due to its ability to protect the amino group during peptide assembly and subsequent deprotection under mild conditions. Z-Arg-OH has been studied for its potential anti-inflammatory and anti-cancer properties, as well as its role in regulating immune responses. It is a promising chemical with potential applications in both research and medicine.

Uses

Used in Peptide Synthesis:
2-(benzyloxycarbonylamino)-4-hydroxybutanoic acid is used as a building block for peptide synthesis for its ability to protect the amino group during peptide assembly and subsequent deprotection under mild conditions.
Used in Pharmaceutical Industry:
2-(benzyloxycarbonylamino)-4-hydroxybutanoic acid is used as a potential therapeutic agent for various diseases, including cancer and inflammatory disorders, due to its potential anti-inflammatory and anti-cancer properties, as well as its role in regulating immune responses.

Upstream product

• 501-53-1 benzyl chloroformate 
• 498-19-1 L-(-)-homoserine 
• 1927-25-9 DL-Homoserine 

Downstream Products

• 116536-02-8 n=5 
• 116506-92-4 n=4 
• 116506-91-3 n=3 
• 116506-90-2 n=2 
• 116506-89-9 n=1 
• 116506-88-8 (S)-2-Benzyloxycarbonylamino-4-[(2R,3R,4R,5S)-5-((R)-1,2-dihydroxy-ethyl)-3,4-dihydroxy-tetrahydro-furan-2-yloxy]-butyric acid 
• 109164-83-2 (R)-2-[(1R,7R,11S)-8-(4-Methoxy-benzyl)-6,9-dioxo-5,8-diaza-tricyclo[5.2.2.0^1,5]undec-11-yl]-propionic acid ethyl ester 
• 109164-83-2 (S)-2-[(1R,7R,11S)-8-(4-Methoxy-benzyl)-6,9-dioxo-5,8-diaza-tricyclo[5.2.2.0^1,5]undec-11-yl]-propionic acid ethyl ester 
• 109164-85-4 (1R,7R,11S)-11-Isopropenyl-8-(4-methoxy-benzyl)-5,8-diaza-tricyclo[5.2.2.0^1,5]undecane-6,9-dione 
• 109164-85-4 (1R,7R,11R)-11-Isopropenyl-8-(4-methoxy-benzyl)-5,8-diaza-tricyclo[5.2.2.0^1,5]undecane-6,9-dione 
• 109164-79-6 8a-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-benzyl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione 
• 109164-82-1 (E)-4-[2-(4-Methoxy-benzyl)-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-8a-yl]-2-methyl-but-2-enoic acid ethyl ester 
• 109164-78-5 4-(3-Bromo-propyl)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-benzyl)-piperazine-2,5-dione 
• 109164-86-5 8a-((E)-4-Hydroxy-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione 

Relevant articles and documents

Synthesis and in vitro enzyme activity of aza, oxa and thia derivatives of bacterial cell wall biosynthesis intermediates

Mechanism based inhibitors of diaminopimelate aminotransferase (DAP-AT) were designed using knowledge of its substrate specificity and mechanism. Synthesis of thiolester and amide substrate analogues was achieved prior to in vitro inhibition studies, but ester analogues proved too unstable to isolate. Thia substrate analogues showed no inhibitory properties, but the aza substrate analogue 12a showed reversible inhibition vs. DAP-AT and time dependent inhibition in the absence of the natural substrate 4. Substrate analogue 12a is thefirst example of an amide inhibitor of PLP dependent enzymes. Antibiotic properties of 12a were also briefly assessed.

Protein binding polyhedral boranes II: DL S (10 dimethylsulfidooctahydrodecaborane)methionine

-