79116-08-8

Basic information

• Product Name: 5-Thiazolecarboxylic acid, 4-(bromomethyl)-2-phenyl-, ethyl ester
• CAS NO: 79116-08-8
• Molecular Formula: C13H12BrNO2S
• Molecular Weight: 326.214
• Mol File: 79116-08-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-Thiazolecarboxylic acid, 4-(bromomethyl)-2-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Thiazolecarboxylic acid, 4-(bromomethyl)-2-phenyl-, ethyl ester(79116-08-8)
• EPA Substance Registry System: 5-Thiazolecarboxylic acid, 4-(bromomethyl)-2-phenyl-, ethyl ester(79116-08-8)

Safety Data

• Hazardous Substances Data: 79116-08-8(Hazardous Substances Data)

Upstream product

• 2227-79-4 benzenecarbothioamide 
• 22900-83-0 ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate 
• 7210-76-6 ethyl-2-amino-4-methylthiazole-5-carboxylate 

Downstream Products

• 440107-15-3 ethyl 2-phenyl-4-(1-pyrrolylmethyl)thiazole-5-carboxylate 
• 88469-80-1 ethyl 4-[(acetyloxy)methyl]-2-phenyl-1,3-thiazole-5-carboxylate 
• 1235473-99-0 ethyl 4-((dimethylamino)methyl)-2-phenylthiazole-5-carboxylate 
• 345293-23-4 2-Phenyl-4-phenylsulfanylmethyl-thiazole-5-carboxylic acid 
• 79116-10-2 2-phenyl-4-phenoxymethylthiazole-5-carboxylic acid 
• 79116-15-7 2-Phenyl-4-phenylsulfanylmethyl-thiazole-5-carbonyl chloride 
• 79116-12-4 4-Phenoxymethyl-2-phenyl-thiazole-5-carbonyl chloride 
• 79116-14-6 2-phenyl-4,10-dihydro-10-oxo<1>benzothiepino<3,4-d>thiazole 
• 79116-11-3 2-phenyl-4,10-dihydro-10-oxo<1>benzoxepino<3,4-d>thiazole 
• 88469-78-7 7-Morpholino-2-phenyl-thiazolo<4,5-d>pyridazin 
• 88469-75-4 2,6-Diphenyl-thiazolo<4,5-d>pyridazin-7-on 
• 88469-73-2 5-Ethoxycarbonyl-4-formyl-2-phenyl-thiazol 
• 88469-79-8 7-Methylthio-2-phenyl-thiazolo<4,5-d>pyridazin 
• 88469-77-6 2-Phenyl-thiazolo<4,5-d>pyridazin-7-thion 

Relevant articles and documents

Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through p Kaand LogD Modulation

Transient receptor potential melastatin 8 (TRPM8) is crucially involved in pain modulation and perception, and TRPM8 antagonists have been proposed as potential therapeutic approaches for pain treatment. Previously, we developed two TRPM8 antagonists and proposed them as drug candidates for topical and systemic pain treatment. Here, we describe the design and synthesis of these two TRPM8 antagonists (27 and 45) and the rational approach of modulation/replacement of bioisosteric chemical groups, which allowed us to identify a combination of narrow ranges of pKa and LogD values that were crucial to ultimately optimize their potency and metabolic stability. Following the same approach, we then pursued the development of new TRPM8 antagonists suitable for the topical treatment of ocular painful conditions and identified two new compounds (51 and 59), N-alkoxy amide derivatives, that can permeate across ocular tissue and reduce the behavioral responses induced by the topical ocular menthol challenge in vivo.

Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors

The present invention provides a compound of formula (1) wherein R1-R5, R25, R26, Y and X2 are defined as in claim 1. The compounds activate human peroxisome proliferator activated receptors (hPPARs) and arc useful for the treatment of associated disorders such as cardiovascular disease and hypercholesteremia.