79127-24-5 Usage
Description
A-7 HYDROCHLORIDE, also known as an analog of the napthalenesulfonamide W-7, is a potent cell-permeable antagonist of calmodulin with an acyl chain length of 10 carbons. It is a white crystalline solid that inhibits Ca2+/calmodulin cyclic nucleotide phosphodiesterase more potently than W-7.
Uses
Used in Pharmaceutical Industry:
A-7 HYDROCHLORIDE is used as a calmodulin antagonist for its ability to inhibit Ca2+/calmodulin cyclic nucleotide phosphodiesterase more potently than W-7, making it a potential candidate for the development of drugs targeting calmodulin-related diseases and conditions.
Used in Research Applications:
A-7 HYDROCHLORIDE is used as a research tool for studying the role of calmodulin in various cellular processes and its interaction with other proteins and enzymes, contributing to a better understanding of its diverse functions in cell function.
Biological Activity
Potent calmodulin antagonist (inhibits calmodulin-activated PDE activity with an IC 50 of 3 μ M).
Check Digit Verification of cas no
The CAS Registry Mumber 79127-24-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,1,2 and 7 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 79127-24:
(7*7)+(6*9)+(5*1)+(4*2)+(3*7)+(2*2)+(1*4)=145
145 % 10 = 5
So 79127-24-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H29ClN2O2S.ClH/c21-19-13-9-12-18-17(19)11-10-14-20(18)26(24,25)23-16-8-6-4-2-1-3-5-7-15-22;/h9-14,23H,1-8,15-16,22H2;1H
