791828-58-5 Usage
Description
Aderbasib, also known as azaspiro[2.5]octanehydroxamide derivative, is a potent inhibitor of metalloproteases. It is a small molecule with significant therapeutic potential, particularly in the treatment of various disorders such as cancer, arthritis, cardiovascular, and skin disorders. Aderbasib works by inhibiting the activity of metalloproteases, which are enzymes involved in the degradation of extracellular matrix proteins and the regulation of cell signaling pathways. Its ability to target these enzymes makes it a promising candidate for pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
Aderbasib is used as an inhibitor of metalloproteases for the treatment of various disorders, including cancer, arthritis, cardiovascular, and skin disorders. By inhibiting metalloproteases, aderbasib can help regulate cell signaling pathways and prevent the degradation of extracellular matrix proteins, which play a crucial role in the progression of these diseases.
Used in Cancer Treatment:
Aderbasib is used as an anticancer agent, targeting metalloproteases that are often overexpressed in cancer cells. This overexpression can contribute to tumor growth, invasion, and metastasis. By inhibiting these enzymes, aderbasib can potentially slow down or halt the progression of cancer, making it a valuable tool in the fight against various types of cancer.
Used in Arthritis Treatment:
In the treatment of arthritis, aderbasib is used as an anti-inflammatory agent. Metalloproteases are involved in the breakdown of cartilage and other joint tissues, leading to the symptoms of arthritis. By inhibiting these enzymes, aderbasib can help reduce inflammation and protect joint tissues, providing relief from arthritis symptoms.
Used in Cardiovascular Disorder Treatment:
Aderbasib is used as a therapeutic agent for cardiovascular disorders, where it can help prevent the degradation of extracellular matrix proteins in blood vessels. This can contribute to the maintenance of vascular integrity and the prevention of conditions such as atherosclerosis and aneurysms.
Used in Skin Disorder Treatment:
In the treatment of skin disorders, aderbasib is used as an agent to inhibit metalloproteases involved in the breakdown of dermal extracellular matrix proteins. This can help maintain the structural integrity of the skin and promote wound healing, making it a valuable tool in the treatment of various skin conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 791828-58-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,9,1,8,2 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 791828-58:
(8*7)+(7*9)+(6*1)+(5*8)+(4*2)+(3*8)+(2*5)+(1*8)=215
215 % 10 = 5
So 791828-58-5 is a valid CAS Registry Number.
791828-58-5Relevant articles and documents
AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES
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, (2015/12/18)
The present invention provides a compound of Formula (I) or Formula (II): enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula (I) and (II) are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.
