791856-59-2

Basic information

• Product Name: 4-(2-phenylimidazol-1-yl)thiobutyramide
• Synonyms: 4-(2-phenylimidazol-1-yl)thiobutyramide
• CAS NO: 791856-59-2
• Molecular Weight: 245.348
• Mol File: 791856-59-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-phenylimidazol-1-yl)thiobutyramide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-phenylimidazol-1-yl)thiobutyramide(791856-59-2)
• EPA Substance Registry System: 4-(2-phenylimidazol-1-yl)thiobutyramide(791856-59-2)

Safety Data

• Hazardous Substances Data: 791856-59-2(Hazardous Substances Data)

Upstream product

• 670-96-2 2-Phenylimidazole 
• 198549-12-1 4-(2-phenyl-1H-imidazol-1-yl)butanenitrile 

Downstream Products

• 791856-70-7 diethyl 1-benzimidoyl-1,2,3,4-tetrahydro-1,5-naphthyridine-6,7-dicarboxylate 
• 791856-50-3 diethyl 3-(3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine-5,6-dicarboxylate 
• 791856-55-8 5-(4-methoxyphenyl)-3-(3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine 
• 791856-54-7 5-(4-bromophenyl)-3-(3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine 
• 791856-48-9 5,6,7,8-tetrahydro-2-(3-(2-phenylimidazol-1-yl)propyl)-4-azaquinazoline 
• 791856-46-7 3-(3-(2-phenylimidazol-1-yl)propyl)-5-phenyl-1,2,4-triazine 
• 791856-68-3 6-(4-bromophenyl)-1,2,3,4-tetrahydro-1,5-naphthyridine 
• 791856-69-4 6-(4-methoxyphenyl)-1,2,3,4-tetrahydro-1,5-naphthyridine 
• 791856-65-0 6-phenyl-1,2,3,4-tetrahydro-1,5-naphthyridine 
• 198549-17-6 5,6-diphenyl-3-(3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine 
• 198549-20-1 5,6-dimethyl-3-(3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine 
• 198549-21-2 3-(3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine 
• 198549-22-3 6,7-diphenyl-1,2,3,4-tetrahydro-1,5-naphthyridine 
• 13993-61-8 1.1,2,3,4-tetrahydro-1,5-naphthyridine 

Relevant articles and documents

Intramolecular inverse-electron-demand Diels-Alder reactions of imidazoles with 1,2,4-triazines: A new route to 1,2,3,4-tetrahydro-1,5-naphthyridines and related heterocycles

The intramolecular inverse-electron-demand Diels-Alder reaction between imidazoles and 1,2,4-triazines linked by a trimethylene tether from the imidazole N1 position to the triazine C3 proceed in excellent yields to produce 1,2,3,4-tetrahydro-1,5-naphthyridines. The reaction proceeds by a cycloaddition with subsequent loss of nitrogen, followed by a presumed stepwise loss of a nitrile. The analogous intramolecular cycloadditions employing a tetramethylene tether also proceeded to give 2,3,4,5-tetrahydro-1H-pyrido[3,2-b]azepines in acceptable yields. The reaction to produce the tetrahydro-1,5-naphthyridines can also be promoted with microwave irradiation.