79222-76-7Relevant articles and documents
Copper-catalyzed aerobic dehydrogenation of C-C to C=C bonds in the synthesis of pyridazinones
Liang, Lei,Yang, Guanyu,Xu, Fengrong,Niu, Yan,Sun, Qi,Xu, Ping
supporting information, p. 6130 - 6136 (2013/09/24)
A simple and efficient procedure for the synthesis of pyridazin-3(2H)-ones through copper-catalyzed dehydrogenation of a single C-C bond of 4,5-dihydropyridazin-3(2H)-ones to a C=C bond with oxygen as the terminal oxidant is described. Functional groups including hydroxy, carboxylic, bromo, chloro, cyano, nitro and alkoxy were all tolerated under the reaction conditions. Moreover, this methodology was applied to the preparation of a series of structurally similar N-substituted 6-phenylpyridazinone compounds containing fluorine. The dehydrogenation reactions exhibit good yields and selectivity. Copper-catalyzed dehydrogenation of a C-C bond of 4,5-dihydropyridazinones to a C=C bond with oxygen as the terminal oxidant is described. Various functional groups were tolerated under the reaction conditions. The method was also applied to the preparation of a series of N-substituted 6-phenylpyridazinones containing fluoride. The dehydrogenation reactions exhibit good yields and selectivity.
SYNTHESE D'ACYL-ALKYLIDENE-3 DIHYDROPYRIDAZINES PAR UNE REACTION D'EXTRUSION DE SOUFRE
Joliveau, Claudine,Wermuth, Camille-Georges
, p. 2295 - 2302 (2007/10/02)
Des acyl-alkylidene-3 dihydropyridazines sont obtenues par une reaction mettant en jeu l'extrusion du soufre des acyl-alkylthio-3 pyridazines N-alkylees correspondantes.Cette reaction d'extrusion n'a pas lieu sur des cycles pyridaziniques non alkyles sur
