79241-07-9Relevant articles and documents
Synthesis of Bioactive Side-Chain Analogues of TAN-2483B
Somarathne, Kalpani K.,McCone, Jordan A. J.,Brackovic, Amira,Rivera, José Luis Pinedo,Fulton, J. Robin,Russell, Euan,Field, Jessica J.,Orme, Christopher L.,Stirrat, Hedley L.,Riesterer, Jasmin,Teesdale-Spittle, Paul H.,Miller, John H.,Harvey, Joanne E.
, p. 1230 - 1237 (2019)
The fungal metabolite TAN-2483B has a 2,6-trans-relationship across the pyran ring of its furo[3,4-b]pyran-5-one core, which has thwarted previous attempts at its synthesis. We have now developed a chiral pool approach to this core and prepared side-chain
Norrisolide: Total synthesis and related studies
Brady, Thomas P.,Kim, Sun Hee,Wen, Ke,Kim, Charles,Theodorakis, Emmanuel A.
, p. 7175 - 7190 (2007/10/03)
A stereoselective synthesis of (+)-norrisolide is presented. This natural product belongs to a family of marine spongiane diterpenes the structure of which is characterized by a fused γ-lactone-γ-lactol ring system attached to a bicyclic hydrophobic core.
Synthetic studies on norrisolide: Enantioselective synthesis of the norrisane side chain
Kim, Charles,Hoang, Richard,Theodorakis, Emmanuel A.
, p. 1295 - 1297 (2008/02/09)
Norrisolide (1) belongs to a family of marine diterpenes that are characterized by the assembly of a bicyclic core with a unique and highly oxygenated side chain (norrisane side chain). As a prelude to the synthesis of 1, we present herein a short, effici