792898-30-7Relevant articles and documents
CONVERSION OF DOPA TO TETRAHYDROISOQUINOLINES AND STIZOLOBIC ACID IN A CALLUS CULTURE OF STIZOLOBIUM HASSJOO
Saito, Koshi,Obata-Sasamoto, Hamako,Hatanaka, Shin-Ichi,Noguchi, Hiroshi,Sankawa, Ushio,Komamine, Atsushi
, p. 474 - 476 (1982)
Isolation and identification of L-3-carboxy-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and L-1-methyl 3-carboxy-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline from seeds and callus of S. hassjoo are described.Administration of -labelled DOPA to a callus culture of this legume resulted in the incorporation of radioactivity into L-3-carboxy-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, L-1-methyl-3-carboxy-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and stizolobic acid, which was confirmed by constant specific radioactivity after co-crystallization with authentic samples of each compound. - Key Word Index - Stizolobium hassjoo; Leguminosae; Yokohama velvet bean; tetrahydroisoquinolines; stizolobic acid; DOPA; callus culture.
Preparation of chiral 1,2,3,4-tetrahydro-6,7-dialkoxy-3-isoquinolinecarboxylic acid and derivatives
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Page/Page column 2-3; 5-6; 8; 12, (2008/06/13)
The present invention relates to a process for the production of (S)-1,2,3,4-tetrahydro-6,7-dialkoxy-3-isoquinolinecarboxylic acid compounds (1) and their derivatives from Levodopa (L-Dopa). The ultimately prepared compounds are used as intermediates for, but not limited to, the preparation of substituted derivatives of 1,2,3,4-tetrahydro-6,7-dialkoxy-3-isoquinolinecarboxylic acid wherein R1is hydrogen, lower alkyl, C2-C12 acyl, or R1O together are methylenedioxy; R2is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, substituted aryl, aralkyl or substituted aralkyl group; and R3is hydrogen, C2-C12 acyl group, benzyl, alkoxylcarbonyl group, or aralkoxyl carbonyl group.
A new efficient synthetic process for the construction of the pentacyclic core of marine alkaloid ecteinascidins
Tang, Ye-Feng,Liu, Zhan-Zhu,Chen, Shi-Zhi
, p. 7091 - 7094 (2007/10/03)
The pentacyclic core of ecteinascidins was constructed from two fundamental building blocks, the 1,2,3,4-tetrahydroisoquinoline derivative and the substituted phenylalanine derivative, via 8 steps using readily available L-Dopa as starting material. The k