792953-14-1

Basic information

• Product Name: 5-aMino-1-(2-chloro-phenyl)-1H-pyrazole-4-carboxylic acid aMide
• Synonyms: 5-aMino-1-(2-chloro-phenyl)-1H-pyrazole-4-carboxylic acid aMide;5-Amino-1-(2-chlorophenyl)-1H-pyrazole-4-carboxamide
• CAS NO: 792953-14-1
• Molecular Formula: C₁₀H₉ClN₄O
• Molecular Weight: 236.65766
• Mol File: 792953-14-1.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-aMino-1-(2-chloro-phenyl)-1H-pyrazole-4-carboxylic acid aMide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-aMino-1-(2-chloro-phenyl)-1H-pyrazole-4-carboxylic acid aMide(792953-14-1)
• EPA Substance Registry System: 5-aMino-1-(2-chloro-phenyl)-1H-pyrazole-4-carboxylic acid aMide(792953-14-1)

Safety Data

• Hazardous Substances Data: 792953-14-1(Hazardous Substances Data)

Upstream product

• 10449-07-7 (2-chlorophenyl)hydrazine 
• 37858-68-7 α-Cyano-β-dimethylaminoacrylamide 
• 64096-89-5 5-amino-1-(2-chlorophenyl)-1H-pyrazole-4-carbonitrile 

Downstream Products

• 1251465-35-6 C₁₁H₇ClN₄O₂ 
• 1251465-35-6 C₁₁H₇ClN₄O₂ 
• 1351413-54-1 2-((1-(2-chlorophenyl)-4-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-N-phenylpropanamide 
• 1351413-55-2 2-((1-(2-chlorophenyl)-4-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-N-(4-methoxyphenyl)propanamide 
• 1399821-46-5 2-((1-(2-chlorophenyl)-4-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-N-(4-ethoxyphenyl)propanamide 
• 1251465-36-7 C₁₁H₅Cl₃N₄ 
• 1006597-09-6 1-(2-chloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 1207760-89-1 2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thio}-4-(2-methoxyethoxy)-N-(4-methyl-1,3-thiazol-2-yl)butanamide 
• 1207760-91-5 2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thio}-4-methoxy-N-(4-methyl-1,3-thiazol-2-yl)butanamide 
• 1207760-97-1 2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thio}-N-(4-methyl-1,3-thiazol-2-yl)hexanamide 
• 1415025-08-9 C₁₇H₁₄ClN₇OS 
• 1415025-07-8 C₁₇H₁₂ClN₇OS 
• 1415025-06-7 C₁₉H₁₅ClN₆OS 
• 852313-98-5 4-chloro-1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine 

Relevant articles and documents

The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold

Glucokinase is a key enzyme in glucose homeostasis since it phosphorylates glucose to give glucose-6-phosphate, which is the first step in glycolysis. GK activators have been proven to lower blood-glucose, and therefore have potential as treatments for type 2 diabetes. Here the discovery of pyrazolopyrimidine GKAs is reported. An original singleton hit from a high-throughput screen with micromolar levels of potency was optimised to give compounds with nanomolar activities. Key steps in this success were the introduction of an extra side-chain, which increased potency, and changing the linking functionality from a thioether to an ether, which led to improved potency and lipophilic ligand efficiency. This also led to more stable compounds with improved profiles in biological assays.

ANTIVIRAL PYRIMIDINES

Disclosed herein are novel compounds comprising substituted pyrimidines, pyrazolopyrimtdines, and imidazolopyrimidines, the syntheses thereof, and compositions thereof, including pharmaceutical compositions, comprising the novel pyrimidines, pyrazolopyrimtdines, imidazolpyrimidines and related compounds. Such compounds function to inhibit entry of viruses of the Flaviviridae family, including Hepatitis C virus (HCV), into cells that are susceptible to virus infection. These compounds are useful for the treatment, therapy and/or prophylaxis of viral diseases and infection, including HCV infection.

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators

This letter describes the synthesis and SAR, developed through an iterative analogue library approach, of an mGluR4 positive allosteric modulator lead based on a pyrazolo[3,4-d]pyrimidine scaffold. Despite tremendous therapeutic potential, Compound 7, VU0080421, and related congeners represent only a handful of mGluR4 positive allosteric modulators ever described.