79315-62-1

Basic information

• Product Name: 4-(benzyloxy)-1-(phenylsulfonyl)-1H-indole
• Synonyms: 4-(benzyloxy)-1-(phenylsulfonyl)-1H-indole
• CAS NO: 79315-62-1
• Molecular Formula: C₂₁H₁₇NO₃S
• Molecular Weight: 363.42958
• EINECS: -0
• Mol File: 79315-62-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(benzyloxy)-1-(phenylsulfonyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(benzyloxy)-1-(phenylsulfonyl)-1H-indole(79315-62-1)
• EPA Substance Registry System: 4-(benzyloxy)-1-(phenylsulfonyl)-1H-indole(79315-62-1)

Safety Data

• Hazardous Substances Data: 79315-62-1(Hazardous Substances Data)

Usage

General Description

4-(benzyloxy)-1-(phenylsulfonyl)-1H-indole is a chemical compound that belongs to the class of indole derivatives. It is characterized by the presence of a benzyl ether group and a phenylsulfonyl group attached to the indole ring. 4-(benzyloxy)-1-(phenylsulfonyl)-1H-indole has potential pharmaceutical applications due to its structural features, which may impart biological activity. The benzyl ether and phenylsulfonyl groups are known to influence the compound's solubility and reactivity, making it a valuable building block for the synthesis of novel drug candidates and bioactive molecules. Additionally, the indole ring structure is of interest in medicinal chemistry, as it is commonly found in biologically active compounds. Therefore, 4-(benzyloxy)-1-(phenylsulfonyl)-1H-indole is a promising chemical entity for further exploration and development in the field of pharmaceutical research and drug discovery.

InChI:InChI=1S/C21H17NO3S/c23-26(24,18-10-5-2-6-11-18)22-15-14-19-20(22)12-7-13-21(19)25-16-17-8-3-1-4-9-17/h1-15H,16H2

Upstream product

• 144024-38-4 3-(1,3-dioxolan-2-yl)-1-<1-(phenylsulfonyl)-3-pyrrolyl>-1-propanone 
• 100-51-6 benzyl alcohol 
• 157396-11-7 7-(4-chlorophenylthio)-6,7-dihydro-1-(phenylsulfonyl)-1H-indol-4(5H)-one 
• 157396-13-9 ethyl 4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoate 
• 157396-14-0 4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoyl chloride 
• 16851-82-4 N-phenylsulfonylpyrrole 
• 20289-26-3 4-benzyloxy-1H-indole 
• 98-09-9 benzenesulfonyl chloride 
• 2380-94-1 1H-indol-4-ol 
• 100-39-0 benzyl bromide 

Downstream Products

• 20289-26-3 4-benzyloxy-1H-indole 
• 889675-05-2 1-(4-(benzyloxy)-1-(phenylsulfonyl)-1H-indol-2-yl)ethanone 

Relevant articles and documents

Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT6 receptor with anti-aggregation properties against amyloid-beta and tau

Multifunctional ligands as an essential variant of polypharmacology are promising candidates for the treatment of multi-factorial diseases like Alzheimer's disease. Based on clinical evidence and following the paradigm of multifunctional ligands we have r

MAP4K4 (HGK) Inhibitors

The invention provides mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) inhibitors, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant diminution of tumor cell growth, cancer or metastasis.

The first potent inhibitor of mammalian group X secreted phospholipase A2: Elucidation of sites for enhanced binding

Using the X-ray structure of human group X secreted phospholipase A 2 (hGX), we carried out structure-based design of indole-based inhibitors and prepared the compounds using a new synthetic route. The most potent compound inhibited hGX and the mouse orthologue with an IC50 of 75 nM. This compound is the most potent hGX inhibitor reported to date and was also found to inhibit a subset of the other mouse and human SPLA 2S.