79322-93-3

Basic information

• Product Name: 3-[4-(4-chlorophenyl)piperazin-1-yl]propan-1-amine
• Synonyms: 3-[4-(4-chlorophenyl)piperazin-1-yl]propan-1-amine
• CAS NO: 79322-93-3
• Molecular Weight: 253.775
• Mol File: 79322-93-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-[4-(4-chlorophenyl)piperazin-1-yl]propan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(4-chlorophenyl)piperazin-1-yl]propan-1-amine(79322-93-3)
• EPA Substance Registry System: 3-[4-(4-chlorophenyl)piperazin-1-yl]propan-1-amine(79322-93-3)

Safety Data

• Hazardous Substances Data: 79322-93-3(Hazardous Substances Data)

Upstream product

• 79322-92-2 3-[4-(4-chlorophenyl)-piperazin-1-yl]-propionitrile 
• 124846-92-0 2-{3-[4-(4-chlorophenyl)piperazin-1-yl]propyl}-1H-isoindole-1,3(2H)-dione 
• 38212-33-8 4-(4-chlorophenyl) piperazine 

Downstream Products

• 79323-07-2 1-{3-[4-(4-Chloro-phenyl)-piperazin-1-yl]-propyl}-4-(4-methoxy-phenyl)-piperidine-2,6-dione 
• 1240266-72-1 C₂₆H₃₃ClN₄O*ClH 
• 27105-86-8 N-{3-[4-(4-chlorophenyl)piperazin-1-yl]propyl}thiophene-2-carboxamide 
• 1360625-46-2 N-{3-[4-(4-chlorophenyl)piperazin-1-yl]propyl}-4-isoquinolinesulfonamide hydrochloride 
• 1360684-66-7 N-{3-[4-(4-chlorophenyl)piperazin-1-yl]propyl}-4-isoquinolinesulfonamide 
• 1360625-45-1 N-{3-[4-(4-chlorophenyl)piperazin-1-yl]propyl}-3-quinolinesulfonamide hydrochloride 
• 1360684-65-6 N-{3-[4-(4-chlorophenyl)piperazin-1-yl]propyl}-3-quinolinesulfonamide 

Relevant articles and documents

Benzyl Phenylsemicarbazides: A Chemistry-Driven Approach Leading to G Protein-Biased Dopamine D4 Receptor Agonists with High Subtype Selectivity

Many subtype-selective dopamine receptor ligands developed for the D2-D4 family incorporate a 1-arylpiperazine-derived primary recognition motif, which is connected to a lipophilic moiety occupying an extended binding pocket (EBP) of the receptor via an aliphatic linker of variable lengths. The evaluation of a novel group of dopamine receptor ligands now showed that highly subtype-selective ligands [up to Ki(D4.4) = 0.25 nM, D2L/D4.4 = 320, D3/D4.4 = 710 for APH199 (17)] can be obtained by choosing a relatively large and conformationally flexible 1-benzyl-1-phenylsemicarbazide substructure to fill the EBP. The novel chemotype APH199 (17) was found to act as a full agonist at the D4 receptor showing significant bias toward G protein activation over β-arrestin recruitment in comparison to quinpirole.

Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers

T-type calcium channel is one of therapeutic targets for the treatment of cardiovascular diseases and neuropathic pain. In this study, as a part of our ongoing efforts to develop potent T-type calcium channel blockers, we designed oxazole derivatives subs

Synthesis and pharmacology of 1-(4-aryl-1-piperazinyl-alkyl)-4-(4-methoxyphenyl) piperidine-2,6-diones: Tranquilizers

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