793663-51-1 Usage
Description
(R)-3-AMINO-3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID, also known as (R)-3-Amino-3-(3-trifluoromethylphenyl)propanoic acid, is a chiral compound that belongs to the class of 3-substituted-β-alanine derivatives. It is characterized by the presence of an amino group and a trifluoromethylphenyl group attached to the chiral carbon center, which gives rise to its unique stereochemistry and properties.
Uses
Used in Pharmaceutical Industry:
(R)-3-AMINO-3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID is used as an analyte for enantioseparation of 3-substituted-(R,S)-β-alanine derivatives by reversed-phase high-performance liquid chromatography (HPLC). This application is crucial for the development and analysis of chiral drugs, as it allows for the separation and identification of individual enantiomers, which can exhibit different pharmacological activities and potencies.
In the pharmaceutical industry, enantioseparation is essential for ensuring the purity and efficacy of chiral drugs, as well as for studying the stereoselectivity of drug interactions with biological targets. The use of (R)-3-AMINO-3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID as an analyte in enantioseparation by reversed-phase HPLC provides a valuable tool for researchers and pharmaceutical companies to develop and optimize chiral drug candidates with improved therapeutic profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 793663-51-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,9,3,6,6 and 3 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 793663-51:
(8*7)+(7*9)+(6*3)+(5*6)+(4*6)+(3*3)+(2*5)+(1*1)=211
211 % 10 = 1
So 793663-51-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H10F3NO2/c11-10(12,13)7-3-1-2-6(4-7)8(14)5-9(15)16/h1-4,8H,5,14H2,(H,15,16)/t8-/m1/s1
793663-51-1Relevant articles and documents
Iridium-catalysed C-H borylation of β-aryl-aminopropionic acids
MacDonald, Simon J. F.,Nortcliffe, Andrew,Robinson, Henry,Simelis, Klemensas,Stillibrand, Joe
supporting information, p. 6696 - 6701 (2020/09/21)
Iridium-catalysed catalytic, regioselective C-H borylation of β-aryl-aminopropionic acid derivatives gives access to 3,5-functionalised protected β-aryl-aminopropionic acid boronates. The synthetic versatility of these new boronates is demonstrated through sequential one-pot functionalisation reactions to give diverse building blocks for medicinal chemistry. The C-H borylation is also effective for dipeptide substrates. We have exemplified this methodology in the synthesis of a pan αv integrin antagonist.
BENZIMIDAZOLE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS
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Page/Page column 61, (2019/03/12)
The present invention relates to compounds of the general formula (I). The compounds of formula I are potassium channel inhibitors useful for treatment of a cardiac disease, disorder or condition in a mammal.
Microwave Assisted Synthesis of Trifluoro Substituted 2-Aminobenzimidazole Derivatives via Iodoacetic Acid Mediated One-pot Condensation
Sriram,Sapthagiri,Ilavarasan,Ravi
, p. 2440 - 2446 (2017/07/25)
Microwave-assisted efficient one-pot syntheses of trifluoro substituted 2-aminobenzimidazole derivative were synthesized using iodoacetic acid mediated cyclodesulfurization of thioureas. This method eliminates need to handle preformed substituted thioureas, requires lesser reaction time and temperature, is facile, and also gives higher yields of the target molecules.
