79388-24-2

Basic information

• Product Name: methyl 2,2-dimethyl-3-(N-phenylamino)-3-(2-thienyl)propionate
• Synonyms: methyl 2,2-dimethyl-3-(N-phenylamino)-3-(2-thienyl)propionate
• CAS NO: 79388-24-2
• Molecular Weight: 289.398
• Mol File: 79388-24-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: methyl 2,2-dimethyl-3-(N-phenylamino)-3-(2-thienyl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2,2-dimethyl-3-(N-phenylamino)-3-(2-thienyl)propionate(79388-24-2)
• EPA Substance Registry System: methyl 2,2-dimethyl-3-(N-phenylamino)-3-(2-thienyl)propionate(79388-24-2)

Safety Data

• Hazardous Substances Data: 79388-24-2(Hazardous Substances Data)

Upstream product

• 5918-68-3 N-thiophen-2-ylmethyleneaniline 
• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 98-03-3 thiophene-2-carbaldehyde 
• 62-53-3 aniline 
• 5918-68-3 (E)-N-phenyl-1-(thiophen-2-yl)methanimine 

Downstream Products

• 69187-10-6 3,3-Dimethyl-1-phenyl-4-thiophen-2-yl-azetidin-2-one 

Relevant articles and documents

Mannich-type reaction catalyzed by silica-supported fluoroboric acid under solvent-free conditions

Three-component Mannich-type reaction of aldehydes, aromatic amines, and silyl enolate proceeded smoothly to afford β-amino carbonyl compounds with good yields in the presence of a catalytic amount of HBF4-SiO2. Copyright Taylor & Francis Group, LLC.

Solvent-free imino-aldol three-component couplings on a conveniently-prepared and reusable phosphoric acid-silica gel support

A new solvent-free procedure for the synthesis of β-amino carbonyl compounds in generally moderate to excellent yields has been developed. Three-component Mannich-type couplings between aldehydes (aromatic, aliphatic, alicyclic, and heterocyclic), aromatic amines and silyl enol equivalents proceeded smoothly on a conveniently prepared and reusable phosphoric acid-silica gel solid support.

One-pot Mannich-type reaction in water: HBF4 catalyzed condensation of aldehydes, amines, and silyl enolates for the synthesis of β-amino carbonyl compounds

HBF4 catalyzed Mannich-type reactions of aldehydes, amines, and silyl enolates took place smoothly in water in the presence of a surfactant to afford β-amino carbonyl compounds in high yields. Thieme Stuttgart.