79407-01-5

Basic information

• Product Name: 5-(2-{Benzyl-[2-hydroxy-4-(2-methoxy-phenyl)-butyl]-amino}-ethoxy)-2-hydroxy-benzamide
• Synonyms: 5-(2-{Benzyl-[2-hydroxy-4-(2-methoxy-phenyl)-butyl]-amino}-ethoxy)-2-hydroxy-benzamide
• CAS NO: 79407-01-5
• Molecular Weight: 464.561
• Mol File: 79407-01-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(2-{Benzyl-[2-hydroxy-4-(2-methoxy-phenyl)-butyl]-amino}-ethoxy)-2-hydroxy-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-{Benzyl-[2-hydroxy-4-(2-methoxy-phenyl)-butyl]-amino}-ethoxy)-2-hydroxy-benzamide(79407-01-5)
• EPA Substance Registry System: 5-(2-{Benzyl-[2-hydroxy-4-(2-methoxy-phenyl)-butyl]-amino}-ethoxy)-2-hydroxy-benzamide(79407-01-5)

Safety Data

• Hazardous Substances Data: 79407-01-5(Hazardous Substances Data)

Upstream product

• 74454-60-7 2,3-dihydro-2,2-dimethyl-6-(2-bromoethoxy)-4H-1,3-benzoxazin-4-one 
• 74469-70-8 2,3-dihydro-2,2-dimethyl-6-hydroxy-4H-1,3-benzoxazin-4-one 
• 52405-73-9 gentisamide 
• 63667-83-4 1-(but-3-en-1-yl)-2-methoxybenzene 
• 52289-93-7 o-Methoxybenzyl bromide 
• 71813-53-1 1,2-epoxy-4-(o-methoxyphenyl)butane 
• 76813-69-9 5-[2-(benzylamino)-ethoxy]-salicylamide 

Downstream Products

• 89789-96-8 2-Hydroxy-5-{2-[2-hydroxy-4-(2-methoxy-phenyl)-butylamino]-ethoxy}-benzamide 

Relevant articles and documents

β-Adrenergic blocking agents: Substituted phenylalkanolamines. Effect of side-chain length on β-blocking potency in vitro

The synthesis of a group of potential β-blockers bearing a new 5-ethoxysalicylamide substituent on nitrogen is described. These compounds were tested for β-adrenergic blocking potency in vitro and compared with analogous compounds bearing a tert-butyl group on nitrogen. The new N-substituent increased the β-blocking potency substantially. In a series of five homologous compounds of the type Ar(CH2)(n)CHOHCH2NHR (R = 5-ethoxysalicylamide; n = 0-4), two maxima of β-blocking potency were found for n = 0 and 2. Moreover, the carbon isostere of the corresponding (aryloxy)propanolamine still proved to be a very potent β-blocker. The ether oxygen in the side chain is therefore not an absolute requirement for activity. Structure-activity relationships are discussed.