79419-73-1

Basic information

• Product Name: (RS)-3-(4-fluorophenyl)-3-hydroxy-indolin-2-one
• Synonyms: (RS)-3-(4-fluorophenyl)-3-hydroxy-indolin-2-one
• CAS NO: 79419-73-1
• Molecular Weight: 243.237
• Mol File: 79419-73-1.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: (RS)-3-(4-fluorophenyl)-3-hydroxy-indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-3-(4-fluorophenyl)-3-hydroxy-indolin-2-one(79419-73-1)
• EPA Substance Registry System: (RS)-3-(4-fluorophenyl)-3-hydroxy-indolin-2-one(79419-73-1)

Safety Data

• Hazardous Substances Data: 79419-73-1(Hazardous Substances Data)

Upstream product

• 91-56-5 indole-2,3-dione 
• 282549-48-8 3-(4-fluorophenyl)indolin-2-one 
• 59-48-3 2-oxoindole 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 352-13-6 4-flourophenylmagnesium bromide 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 77014-89-2 3-(4-Fluoro-phenyl)-3-imidazol-1-yl-1,3-dihydro-indol-2-one 
• 1567850-39-8 (S)-tert-butyl 3-(4-fluorophenyl)-3-(trifluoromethanesulfenyl)-2-oxoindoline-1-carboxylate 
• 862907-06-0 tert-butyl 3-(4-fluorophenyl)-2-oxoindoline-1-carboxylate 
• 1588428-28-7 C₁₅H₉F₄NOS 

Relevant articles and documents

Electrochemical Rearrangement of 3-Hydroxyoxindoles into Benzoxazinones

We report an unexpected rearrangement of 3-hydroxyoxindoles into benzoxazinones using electrochemistry. Our reaction employs mild and environmentally friendly conditions, and the benzoxazinone products are obtained in moderate to excellent yields. Mechanistic experiments suggest that a peroxide intermediate is likely involved.

Counterion Control of t-BuO-Mediated Single Electron Transfer to Nitrostilbenes to Construct N-Hydroxyindoles or Oxindoles

tert-Butoxide unlocks new reactivity patterns embedded in nitroarenes. Exposure of nitrostilbenes to sodium tert-butoxide was found to produce N-hydroxyindoles at room temperature without an additive. Changing the counterion to potassium changed the reaction outcome to yield solely oxindoles through an unprecedented dioxygen-transfer reaction followed by a 1,2-phenyl migration. Mechanistic experiments established that these reactions proceed via radical intermediates and suggest that counterion coordination controls whether an oxindole or N-hydroxyindole product is formed.

Organocatalytic stereoselective conjugate addition of 3-substituted oxindoles with in situ generated ortho-quinone methides

A novel method for the stereoselective conjugate addition of 3-substituted oxindoles to in situ generated o-QMs was described. This process was catalyzed efficiently by a cinchonidine-derived squaramide catalyst in oil-water phase, furnishing the corresponding 3,3-disubsituted oxindole derivatives in moderate to high yields (up to 98%) with high stereoselectivities (up to 95% ee, 15.4:1 dr). The utility of this reaction was also investigated by the gram-scale synthesis and derivatization of one of the products.