794479-71-3

Basic information

• Product Name: 1-Pyrrolidinecarboxamide, N-[(3R)-1-[3-(4-chlorophenyl)propyl]-3-pyrrolidinyl]-N-methyl-3-[methyl[[ 4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)-
• CAS NO: 794479-71-3
• Molecular Formula: C34H38ClF3N4O2
• Molecular Weight: 627.15
• Mol File: 794479-71-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxamide, N-[(3R)-1-[3-(4-chlorophenyl)propyl]-3-pyrrolidinyl]-N-methyl-3-[methyl[[ 4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxamide, N-[(3R)-1-[3-(4-chlorophenyl)propyl]-3-pyrrolidinyl]-N-methyl-3-[methyl[[ 4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)-(794479-71-3)
• EPA Substance Registry System: 1-Pyrrolidinecarboxamide, N-[(3R)-1-[3-(4-chlorophenyl)propyl]-3-pyrrolidinyl]-N-methyl-3-[methyl[[ 4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)-(794479-71-3)

Safety Data

• Hazardous Substances Data: 794479-71-3(Hazardous Substances Data)

Upstream product

• 762285-68-7 4'-Trifluoromethyl-biphenyl-4-carboxylic acid methyl-(S)-pyrrolidin-3-yl-amide 
• 762285-62-1 {(S)-1-[((R)-1-Benzyl-pyrrolidin-3-yl)-methyl-carbamoyl]-pyrrolidin-3-yl}-methyl-carbamic acid tert-butyl ester 
• 762285-63-2 Methyl-[(S)-1-((R)-methyl-pyrrolidin-3-yl-carbamoyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester 
• 144043-17-4 (3R)-1-benzyl-N-methylpyrrolidin-3-amine 
• 75677-02-0 3-(4-chlorophenyl)propionaldehyde 
• 762285-95-0 (S)-3-Methylamino-pyrrolidine-1-carboxylic acid {(R)-1-[3-(4-chloro-phenyl)-propyl]-pyrrolidin-3-yl}-methyl-amide 
• 195457-71-7 4-[4-(trifluoromethyl)phenyl]benzoic acid 

Relevant articles and documents

Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists

Ureas derived from two substituted 3-aminopyrrolidine subunits were prepared as constrained analogs of a linear lead compound and tested as antagonists of the MCH1 receptor. The series was optimized for substitution and stereochemistry to generate a functional antagonist with a Ki of 3.3 nM and IC50 of 12 nM (GTPγS).