794525-96-5

Basic information

• Product Name: 2-Butanone, 3-methyl-1-[2-[(S)-(4-methylphenyl)sulfinyl]phenyl]-
• CAS NO: 794525-96-5
• Molecular Formula: C18H20O2S
• Molecular Weight: 300.422
• Mol File: 794525-96-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Butanone, 3-methyl-1-[2-[(S)-(4-methylphenyl)sulfinyl]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanone, 3-methyl-1-[2-[(S)-(4-methylphenyl)sulfinyl]phenyl]-(794525-96-5)
• EPA Substance Registry System: 2-Butanone, 3-methyl-1-[2-[(S)-(4-methylphenyl)sulfinyl]phenyl]-(794525-96-5)

Safety Data

• Hazardous Substances Data: 794525-96-5(Hazardous Substances Data)

Upstream product

• 10381-68-7 (S)-2-methyl-1-(p-tolylsulfinyl)benzene 
• 97-62-1 Ethyl isobutyrate 
• 78-82-0 Isobutyronitrile 

Downstream Products

• 1101249-56-2 (S)-4-methyl-2-[2-(p-tolylsulfinyl)phenyl]pent-1-en-3-one 
• 877200-90-3 (2R)-2-hydroxy-3-methyl-2-[2-(p-tolylthio)benzyl]butanamide 
• 877200-84-5 [2R,(S)S]-2-hydroxy-3-methyl-2-[2-(p-tolylsulfinyl)benzyl]butanenitrile 
• 63674-19-1 (R)-3-Methyl-1-phenyl-2-butanol 

Relevant articles and documents

Synthesis of chiral ortho-(p-tolylsulfinyl) benzyl ketones

(S)-ortho-(p-Tolylsulfinyl)benzyl alkyl (and aryl) ketones 1a-e were prepared in good yields by reaction of esters or nitriles with the lithium benzyl carbanion derived from 2-(p-tolylsulfinyl) methylbenzene. α-Methylbenzyl ketones 2 were prepared as ca. 1:1 diastereoisomeric mixtures by methylation of the unsubstituted ketones 1 with NaH/MeI. The use of the ethylbenzene derivative as the starting material afforded complex mixtures. The obtention of pure (S,(S)S)-2 diastereoisomers could be attained in good yields by oxidation with PCC of the alcohols (epimeric mixtures at the hydroxylic carbon) obtained from reactions of aldehydes with the lithium carbanion derived from 2-(p-tolylsulfinyl)ethylbenzene. Graphical Abstract