79456-34-1

Basic information

• Product Name: 2-Amino-5-bromo-3-(trifluoromethyl)pyridine
• Synonyms: 2-Amino-5-bromo-3-(trifluoromethyl)pyridine;2-Amino-3-trifluoro-5-bromopyridine;5-BROMO-3-(TRIFLUOROMETHYLl)PYRIDIN-2-AMINE;5-Bromo-3-(trifluoromethyl)pyridin-2-amine, 2-Amino-5-bromo-alpha,alpha,alpha-trifluoro-3-picoline;2-Pyridinamine, 5-bromo-3-(trifluoromethyl)-
• CAS NO: 79456-34-1
• Molecular Formula: C₆H₄BrF₃N₂
• Molecular Weight: 241.0085696
• Mol File: 79456-34-1.mol
• Article Data: 28

Chemical Properties

• Melting Point: 90 °C
• Boiling Point: 216.6 °C at 760 mmHg
• Flash Point: 84.8 °C
• Appearance: /
• Density: 1.79 g/cm³
• Vapor Pressure: 0.139mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Room temperature.
• PKA: 1.93±0.49(Predicted)
• CAS DataBase Reference: 2-Amino-5-bromo-3-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-bromo-3-(trifluoromethyl)pyridine(79456-34-1)
• EPA Substance Registry System: 2-Amino-5-bromo-3-(trifluoromethyl)pyridine(79456-34-1)

Safety Data

• RIDADR: UN2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 79456-34-1(Hazardous Substances Data)

Usage

General Description

2-Amino-5-bromo-3-(trifluoromethyl)pyridine is a chemical compound with the molecular formula C6H4BrF3N2. It belongs to the class of pyridine compounds and contains a bromine atom and a trifluoromethyl group. 2-Amino-5-bromo-3-(trifluoromethyl)pyridine is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Its unique structure and functional groups make it a valuable building block in organic synthesis. It is important to handle and use this chemical with caution, as it may have potential health hazards and is harmful if ingested or inhaled.

InChI:InChI=1/C6H4BrF3N2/c7-3-1-4(6(8,9)10)5(11)12-2-3/h1-2H,(H2,11,12)

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 887144-94-7 Togni's reagent II 
• 183610-70-0 2-amino-3-trifluoromethylpyridine 

Downstream Products

• 1083429-59-7 N-(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-4-morpholin-4-yl-benzamide 
• 1083429-55-3 1-(3-{5-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-propyl)-3-(3-methoxy-phenyl)-urea 
• 1083430-94-7 C₂₈H₃₁F₃N₆O₄ 
• 1083429-84-8 (2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-carbamic acid tert-butylester 
• 1083430-95-8 5-{6-[3-(3-amino-propoxy)-4-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine 
• 1083428-92-5 5-{6-[4-(2-amino-ethoxy)-3-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine 
• 1083430-93-6 C₂₀H₁₆F₃N₅O₂ 
• 1121053-29-9 (3-chloro-6-furan-3-yl-8-trifluoromethyl-imidazo[1,2-a]pyridin-2-yl)-[3-(2-fluoro-phenyl)-pyrrolidin-1-yl]-methanone 
• 1284243-18-0 4-{[3-chloro-6-(3-furanyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclohexyl-2-piperazinone 
• 1121055-25-1 (3-chloro-6-furan-3-yl-8-trifluoromethyl-imidazo[1,2-a]pyridine-2-yl)-(4-phenyl-piperazin-1-yl)-methanone 
• 1284243-09-9 4-{[3-chloro-6-(3-furanyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-phenyl-2-piperazinone 
• 1366050-29-4 2-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-1H-imidazo[4,5-c]cinnolin-1-yl)phenyl)-2-methylpropanenitrile 
• 1366047-63-3 2-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)phenyl)-2-methylpropanenitrile 
• 1189126-37-1 6-amino-5-(trifluoromethyl)pyridin-3-ylboronic acid 

Relevant articles and documents

Synthesis method and applications of polysubstituted 2-aminopyridine derivative

The invention belongs to the field of organic synthetic chemistry, and relates to a synthetic method and applications of a polysubstituted 2-aminopyridine derivative. According to the method, a 1,2,3-triazine compound and a cyanomethyl compound are used as substrates and are subjected to a one-step cycloaddition reaction under an alkaline condition to obtain a polysubstituted 2-aminopyridine derivative, wherein the reaction does not involve in danger and control reagents and medicines, and a simple, safe, efficient and environment-friendly strategy is provided for synthesizing the polysubstituted 2-aminopyridine derivative. According to the present invention, the obtained product is subjected to further derivatization, such that the active molecule or the drug molecule containing the 2-aminopyridine structure can be synthesized, such as active molecule SC-53606, drug molecule apatinib and nevirapine.

HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES

Provided herein are Heterocyclic compounds of formula (I): and pharmaceutically acceptable salts, tautomers, isotopologues, or stereoisomers thereof, wherein W, X, Y, R1, R2, and RN are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound, and methods for treating or preventing animal and human filarial worm infections and diseases.

SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS

Disclosed are compounds of the general formula (I), wherein R1-R3 are as defined herein, for use as MALT1 inhibitors in the treatment of autoimmune and inflammatory diseases or disorders. Methods of synthesizing the compounds are also disclosed. Also disc