79479-06-4Relevant articles and documents
Ammonolysis of N-Acylpyroglutamic Acid. Permanganate oxidation of Peptides. II.
Torigoe, Keisuke,Motoki, Yoshiaki,Muramatsu, Ichiro
, p. 1263 - 1264 (1981)
The reaction of N-acylpyroglutamic acid with ammonia proceeds in two pathways.The one results in N-acylglutamine as a product, and the other in pyroglutamic acid and an amide formed from the N-acyl group.The ratio of the yields of the two reactions changes with the N-acyl group, being correlated with the acidity of the carboxylic acid from which the N-acyl group is derived, and also with the steric hindrance of the group.