79520-01-7

Basic information

• Product Name: C₂₁H₁₇NO₅
• Synonyms: C₂₁H₁₇NO₅
• CAS NO: 79520-01-7
• Molecular Weight: 363.37
• Mol File: 79520-01-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₇NO₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₇NO₅(79520-01-7)
• EPA Substance Registry System: C₂₁H₁₇NO₅(79520-01-7)

Safety Data

• Hazardous Substances Data: 79520-01-7(Hazardous Substances Data)

Upstream product

• 616-82-0 3-nitro-4-hydroxybenzoic acid 
• 100-39-0 benzyl bromide 

Downstream Products

• 1418738-51-8 C₂₃H₂₀BrNO₄ 

Relevant articles and documents

Development of hypoxia-inducible factor (HIF)-1α inhibitors: Effect of ortho-carborane substituents on HIF transcriptional activity under hypoxia

A series of substituted ortho-carboranylphenoxyacetanilides were synthesized and evaluated for their ability to inhibit hypoxia-induced HIF-1 transcriptional activity using a cell-based reporter assay in HeLa cells expressing the HRE-dependent firefly luciferase reporter construct (HRE-Luc) and constitutively expressing CMV-driven Renilla luciferase reporter, and their ability to inhibit cell growth (GI50) using the MTT assay. Among the compounds synthesized, 1g and 1l showed significant inhibition of hypoxia-induced HIF-1 transcriptional activity (IC50: 1.9 ± 0.4 and 1.4 ± 0.2 μM, respectively). Both compounds suppressed HIF-1α accumulation in a concentration-dependent manner. The porcine heart malate dehydrogenase (MDH) refolding assay revealed that compound 1l inhibited human Hsp60 chaperone activity (IC50: 6.80 ± 0.25 μM) and this inhibition activity was higher than that of ETB (IC50: 10.9 ± 0.63 μM).